CHMP6 Antibody (PACO39318)
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주문- SKU:
- PACO39318
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CHMP6 Antibody (PACO39318) |
Antibody SKU: | PACO39318 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human, Rat |
Immunogen: | Recombinant Human Charged multivesicular body protein 6 protein (2-201AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO39318 at dilution of 1:100. |
![]() | Western Blot. Positive WB detected in: Rat lung tissue. All lanes: CHMP6 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 24 kDa. Observed band size: 24 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human colon cancer using PACO39318 at dilution of 1:100. |
Background: | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes. |
Synonyms: | Charged multivesicular body protein 6 (Chromatin-modifying protein 6) (Vacuolar protein sorting-associated protein 20) (Vps20) (hVps20), CHMP6, VPS20 |
UniProt Protein Function: | CHMP6: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes. Belongs to the SNF7 family. |
UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: membrane; late endosome membrane; cytosol Molecular Function:protein binding; protein N-terminus binding Biological Process: protein transport; cell separation during cytokinesis; viral reproduction; vacuolar transport; viral infectious cycle; endosome transport; mitotic metaphase plate congression; nuclear organization and biogenesis |
NCBI Summary: | This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. [provided by RefSeq, Mar 2012] |
UniProt Code: | Q96FZ7 |
NCBI GenInfo Identifier: | 73917777 |
NCBI Gene ID: | 79643 |
NCBI Accession: | Q96FZ7.3 |
UniProt Related Accession: | Q96FZ7 |
Molecular Weight: | |
NCBI Full Name: | Charged multivesicular body protein 6 |
NCBI Synonym Full Names: | charged multivesicular body protein 6 |
NCBI Official Symbol: | CHMP6 |
NCBI Official Synonym Symbols: | VPS20 |
NCBI Protein Information: | charged multivesicular body protein 6 |
UniProt Protein Name: | Charged multivesicular body protein 6 |
UniProt Synonym Protein Names: | Chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20; Vps20; hVps20 |
Protein Family: | Charged multivesicular body protein |
UniProt Gene Name: | CHMP6 |
UniProt Entry Name: | CHMP6_HUMAN |
Antibodies |
CHMP6 Antibody (PACO08413) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |