| UniProt Protein Function: | CEACAM3: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3 phosphorylation. CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. Belongs to the immunoglobulin superfamily. CEA family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Immunoglobulin superfamily; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: integral to membrane |
| NCBI Summary: | This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013] |
| UniProt Code: | P40198 |
| NCBI GenInfo Identifier: | 218511974 |
| NCBI Gene ID: | 1084 |
| NCBI Accession: | P40198.2 |
| UniProt Related Accession: | P40198 |
| Molecular Weight: | |
| NCBI Full Name: | Carcinoembryonic antigen-related cell adhesion molecule 3 |
| NCBI Synonym Full Names: | carcinoembryonic antigen related cell adhesion molecule 3 |
| NCBI Official Symbol: | CEACAM3 |
| NCBI Official Synonym Symbols: | CEA; CGM1; W264; W282; CD66D |
| NCBI Protein Information: | carcinoembryonic antigen-related cell adhesion molecule 3 |
| UniProt Protein Name: | Carcinoembryonic antigen-related cell adhesion molecule 3 |
| UniProt Synonym Protein Names: | Carcinoembryonic antigen CGM1; CD_antigen: CD66d |
| UniProt Gene Name: | CEACAM3 |
| UniProt Entry Name: | CEAM3_HUMAN |
