| UniProt Protein Function: | CDK11B: a protein kinase of the CDK family. May act as a negative regulator of the normal cell cycle progression. Nine alternatively spliced isoforms have been described. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform is specifically induced in G2/M phase of the cell cycle. 2 isoforms, SV9 and 7, are produced by alternative initiation at Met-1 and Met-357 resulting in p110 and p58 isoforms, respectively. Deleted or altered frequently in neuroblastoma with amplified MYCN genes. Can be cleaved by caspases and demonstrated to play a role in cell apoptosis.Protein type: Cell cycle regulation; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Apoptosis; EC 2.7.11.22; Protein kinase, CMGC; Motility/polarity/chemotaxis; CMGC group; CDK family; PITSLRE subfamily; CDK/PITSLRE subfamilyChromosomal Location of Human Ortholog: 1p36.33Cellular Component: cytoplasm; nucleusMolecular Function: protein serine/threonine kinase activity; protein binding; cyclin-dependent protein kinase activity; ATP binding; protein kinase activityBiological Process: cell proliferation; mitosis; regulation of transcription, DNA-dependent; apoptosis; regulation of cell cycle; regulation of cell growth; protein amino acid phosphorylation; regulation of mRNA processing |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| UniProt Code: | B7ZVY7 |
| NCBI GenInfo Identifier: | 606215171 |
| NCBI Gene ID: | 984 |
| NCBI Accession: | NP_001278274.1 |
| UniProt Secondary Accession: | B7ZVY7,O95265, Q12817, Q12818, Q12819, Q12820, Q12822 Q8N530, B7ZVY7, J3KTL7 |
| UniProt Related Accession: | B7ZVY7,P21127 |
| Molecular Weight: | 49,555 Da |
| NCBI Full Name: | cyclin-dependent kinase 11B isoform 10 |
| NCBI Synonym Full Names: | cyclin dependent kinase 11B |
| NCBI Official Symbol: | CDK11B |
| NCBI Official Synonym Symbols: | p58; PK58; CDK11; CLK-1; CDC2L1; PITSLREA; p58CLK-1; CDK11-p46; CDK11-p58; p58CDC2L1; CDK11-p110 |
| NCBI Protein Information: | cyclin-dependent kinase 11B |
| UniProt Protein Name: | Cyclin-dependent kinase 11B |
| UniProt Synonym Protein Names: | Cell division cycle 2-like protein kinase 1; CLK-1; Cell division protein kinase 11B; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L1; p58 CLK-1 |
| Protein Family: | |
| UniProt Gene Name: | CDK11B |
| UniProt Entry Name: | CD11B_HUMAN |
