CD71 monoclonal antibody (PE) (AGIM0371)
- SKU:
- AGIM0371
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- HI166
- Conjugation:
- PE
- Applications:
- FC
Frequently bought together:
Description
system_update_altDatasheet
| Product Name: | CD71 monoclonal antibody (PE) |
| Product Code: | AGIM0371 |
| Size: | 100 µL |
| Reactivity: | Human |
| Clone: | HI166 |
| Applications: | Flow Cytometry |
| Conjugate: | PE |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P02786 |
| Background: | CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. CD71 antigen is expressed typically at high level on all proliferating cell, activated cells and erythroblasts or reticulocytes that require iron, but not on resting peripheral blood leucocytes and mature erythrocytes. CD71 antigen is also expressed at high level on cells of most neoplastic cell lines and 29-32% of bone marrow cells. A soluble form of CD71 in serum (plasma) exists besides a membrane form. Monitoring the soluble form of CD71 antigen in plasma is a diagnostic marker of anemia besides assaying plasma ferritin. |
| UniProt Protein Function: | TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 3q29 Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic membrane-bound vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; recycling endosome Molecular Function:double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity Biological Process: regulation of cell growth; regulation of cell proliferation; transferrin transport |
| NCBI Summary: | This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] |
| UniProt Code: | P02786 |
| NCBI GenInfo Identifier: | 108935939 |
| NCBI Gene ID: | 7037 |
| NCBI Accession: | P02786.2 |
| UniProt Secondary Accession: | P02786,Q1HE24, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21 D3DXB0, |
| UniProt Related Accession: | P02786 |
| Molecular Weight: | 84,871 Da |
| NCBI Full Name: | Transferrin receptor protein 1 |
| NCBI Synonym Full Names: | transferrin receptor |
| NCBI Official Symbol: | TFRC |
| NCBI Official Synonym Symbols: | T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46 |
| NCBI Protein Information: | transferrin receptor protein 1 |
| UniProt Protein Name: | Transferrin receptor protein 1 |
| UniProt Synonym Protein Names: | T9; p90; CD_antigen: CD71 |
| Protein Family: | Transferrin receptor protein |
| UniProt Gene Name: | TFRC |
| UniProt Entry Name: | TFR1_HUMAN |
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