CD42b monoclonal antibody (PE) (AGIM0360)

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SKU:
AGIM0360
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
HIP1
Conjugation:
PE
Applications:
FC
Frequently bought together:

Description

system_update_altDatasheet
Product Name:CD42b monoclonal antibody (PE)
Product Code:AGIM0360
Size:100 µL
Reactivity:Human
Clone:HIP1
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:O00291
Background:CD42b (GPIb?±) composes together with GPIb??, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis.
UniProt Protein Function:HIP1: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed. Belongs to the SLA2 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytoskeletal; Apoptosis

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: Golgi apparatus; cytoskeleton; intracellular membrane-bound organelle; clathrin-coated vesicle; membrane; cytoplasm; clathrin coated vesicle membrane; nucleus

Molecular Function:protein binding, bridging; clathrin binding; protein binding; structural constituent of cytoskeleton; actin binding; phosphoinositide binding

Biological Process: regulation of apoptosis; caspase activation; clathrin cage assembly; transcription, DNA-dependent; regulation of transcription, DNA-dependent; apoptosis; endocytosis; cell differentiation; actin cytoskeleton organization and biogenesis; positive regulation of receptor-mediated endocytosis

Disease: Prostate Cancer

NCBI Summary:The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:O00291
NCBI GenInfo Identifier:206729937
NCBI Gene ID:3092
NCBI Accession:O00291.5
UniProt Related Accession:O00291
Molecular Weight:~ 116kDa
NCBI Full Name:Huntingtin-interacting protein 1
NCBI Synonym Full Names:huntingtin interacting protein 1
NCBI Official Symbol:HIP1  
NCBI Official Synonym Symbols:SHON; HIP-I; ILWEQ; SHONbeta; SHONgamma  
NCBI Protein Information:huntingtin-interacting protein 1
UniProt Protein Name:Huntingtin-interacting protein 1
UniProt Synonym Protein Names:Huntingtin-interacting protein I; HIP-I
Protein Family:Histidine permease
UniProt Gene Name:HIP1  
UniProt Entry Name:HIP1_HUMAN

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