CD40 monoclonal antibody (PE) (AGIM0358)

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SKU:

AGIM0358

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Host Species:

Mouse

Isotype:

IgG1

Clone:

HI40a

Conjugation:

Applications:

Description
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Description

Datasheet

Isotype:	IgG1
Host Species:	Mouse
Storage:	Store at 4°C. Avoid prolonged exposure to light.
Uniprot:	P25942
Background:	CD40 is a costimulatory molecule of the TNF receptor superfamily and is expressed on many cell types, such as B cells, monocytes/macrophages, dendritic cells, endothelial cells, fibroblasts or vascular smooth muscle cells. Interaction of CD40 and its ligand CD154 (CD40L) is required for the generation of antibody responses to T-dependent antigens as well as for the development of germinal centers and memory B cells. In monocytes/macrophages CD40 engagement induces production of pro-inflammatory cytokines and chemokines. CD40-CD154 interactions are also critical for development of CD4 T cell-dependent effector functions. CD40 links innate and adaptive immune responses to bacterial stimuli and serves as an important regulator affecting functions of other costimulatory molecules.

UniProt Protein Function:	CD40: a member of the TNF-receptor superfamily. This receptor for CD40L mediates a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3). HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation. Two alternatively spliced isoforms have been reported. Isoform I is a type I membrane protein; isoform II is secreted.
UniProt Protein Details:	Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 20q12-q13.2 Cellular Component: cell surface; integral to plasma membrane; plasma membrane Molecular Function:enzyme binding; protein binding; receptor activity; signal transducer activity; tumor necrosis factor receptor activity; ubiquitin protein ligase binding Biological Process: activation of NF-kappaB transcription factor; cellular calcium ion homeostasis; immune response; multicellular organismal development; positive regulation of GTPase activity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAP kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat1 protein; protein complex assembly; regulation of cell proliferation; regulation of immune response; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway Disease: Immunodeficiency With Hyper-igm, Type 3
NCBI Summary:	This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]
UniProt Code:	P25942
NCBI GenInfo Identifier:	116000
NCBI Gene ID:	958
NCBI Accession:	P25942.1
UniProt Secondary Accession:	P25942,Q53GN5, Q5JY15, Q5U007, Q7M4Q8, Q86YK5, Q9BYU0 E1P5S9,
UniProt Related Accession:	P25942
Molecular Weight:	22,259 Da
NCBI Full Name:	Tumor necrosis factor receptor superfamily member 5
NCBI Synonym Full Names:	CD40 molecule
NCBI Official Symbol:	CD40
NCBI Official Synonym Symbols:	p50; Bp50; CDW40; TNFRSF5
NCBI Protein Information:	tumor necrosis factor receptor superfamily member 5
UniProt Protein Name:	Tumor necrosis factor receptor superfamily member 5
UniProt Synonym Protein Names:	B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD_antigen: CD40
Protein Family:	CD40 ligand
UniProt Gene Name:	CD40
UniProt Entry Name:	TNR5_HUMAN