CD32a/FCGR2A131H Recombinant Protein (RPES3545)

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SKU:
RPES3545
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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Description

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CD32a/FCGR2A131H Recombinant Protein

Human Fc?Rs are divided into three classes designated Fc?RI (CD64); Fc?RII (CD32); and Fc?RIII (CD16); which generate multiple isoforms; are recognized. The activating- type receptor either has or associates non-covalently with an accessory subunit that has an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. Fc?RI binds IgG with high affinity and functions during early immune responses; whereas Fc?RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses.Human CD32; also known as Low affinity immunoglobulin ? Fc region receptor II-a (IgG Fc receptor II-a); Fc?RII A or FCGR2A Protein; is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM-bearing adapter subunit; FcR?; CD32a (Fc?RII A) delivers an activating signal upon ligand binding; and results in the initiation of inflammatory responses including cytolysis; phagocytosis; degranulation; and cytokine production. The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fc? RII B; and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.

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