CD29 monoclonal antibody (FITC) (AGIM0317)

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SKU:
AGIM0317
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
HI29a
Conjugation:
FITC
Applications:
FC
Frequently bought together:

Description

system_update_altDatasheet
Product Name:CD29 monoclonal antibody (FITC)
Product Code:AGIM0317
Size:100 µL
Reactivity:Human
Clone:HI29a
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P05556
Background:CD29 is called VLA-?? chain or platelet GPIIa, and has a broad tissue distribution including lymphocytes, monocytes, platelets, fibroblasts, endothelial cells and weakly on granulocytes, but not on erythrocytes. CD29 is an important adhesion molecule involved cell-cell and cell-extracellular matrix interactions and plays a critical role in the functional activity of lymphocytes by influencing cellular migration patterns as well as by transducing intracellular signals that influence lymphocyte function.
UniProt Protein Function:ITGB1: an integral membrane protein that heterodimerizes with an alpha-3 chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin.. Beta 1 integrins recognize the amino-acid motif RGD in a wide array of ligands. Five alternatively spliced variants with alternate carboxy termini have been described. Two alternatively spliced isoforms have been described. Isoform beta-1a is widely expressed; other isoforms are generally expressed with a more restricted distribution. Isoform beta-1b is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoforms beta-1c and beta-1c-2 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform beta-c-2, rather than isoform beta-1c, is selectively expressed in primary t-cells. Isoform beta-1c is expressed in nonproliferating and differentiated prostate gland epithelial cells. Isoform beta-1d is expressed specifically in striated muscle (skeletal and cardiac muscle).
UniProt Protein Details:

Protein type:Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 10p11.22

Cellular Component: cell surface; cell-cell adherens junction; cytoplasm; filopodium; focal adhesion; lipid raft; membrane; neuromuscular junction; plasma membrane; receptor complex; ruffle; sarcolemma

Molecular Function:actin binding; C-X3-C chemokine binding; cell adhesion molecule binding; coreceptor activity; fibronectin binding; protease binding; protein binding; protein complex binding; protein heterodimerization activity

Biological Process: B cell differentiation; calcium-independent cell-matrix adhesion; cell adhesion mediated by integrin; cell migration; cell-cell adhesion mediated by integrin; cell-matrix adhesion; cell-substrate adhesion; cellular defense response; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; homophilic cell adhesion; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte migration; leukocyte tethering or rolling; mesodermal cell differentiation; positive regulation of apoptosis; positive regulation of GTPase activity; receptor internalization; regulation of immune response; stress fiber formation; transforming growth factor beta receptor signaling pathway

NCBI Summary:Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P05556
NCBI GenInfo Identifier:218563324
NCBI Gene ID:3688
NCBI Accession:P05556.2
UniProt Secondary Accession:P05556,P78466, P78467, Q13089, Q13090, Q13091, Q13212 A8K6N2, D3DRX9, D3DRY3, D3DRY4, D3DRY5,
UniProt Related Accession:P05556
Molecular Weight:88,884 Da
NCBI Full Name:Integrin beta-1
NCBI Synonym Full Names:integrin subunit beta 1
NCBI Official Symbol:ITGB1  
NCBI Official Synonym Symbols:CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA  
NCBI Protein Information:integrin beta-1
UniProt Protein Name:Integrin beta-1
UniProt Synonym Protein Names:Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit beta; CD_antigen: CD29
UniProt Gene Name:ITGB1  

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