CD27 monoclonal antibody (PE) (AGIM0354)

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SKU:

AGIM0354

Product Type:

Antibody

Antibody Type:

Monoclonal Antibody

Reactivity:

Human

Host Species:

Mouse

Isotype:

IgG2a

Clone:

LT27

Conjugation:

Applications:

Description
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Description

Datasheet

Isotype:	IgG2a
Host Species:	Mouse
Storage:	Store at 4°C. Avoid prolonged exposure to light.
Uniprot:	P26842
Background:	CD27 is a transmembrane 55 kDa protein of the nerve growth factor-receptor family, expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells and a subpopulation of B cells. Activation of T cells via TCR-CD3 complex results in upregulation of CD27 expression on the plasma membrane as well as in the release of its soluble 28-32 kDa form, sCD27, detected in the plasma, urine or spinal fluid. This sCD27 is an important pronostic marker of acute and chronic B cell malignamcies. RgpA, a cystein proteinase, although activating T cells through the protease-activated receptors (PARs), degradates CD27 and counteracts T cell activation mediated by CD27 and ist ligand CD70.

UniProt Protein Function:	CD27: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
UniProt Protein Details:	Protein type:Membrane protein, integral; Apoptosis; Receptor, cytokine Chromosomal Location of Human Ortholog: 12p13 Cellular Component: integral to plasma membrane; neuron projection; nucleus; plasma membrane Molecular Function:caspase inhibitor activity; protein binding; tumor necrosis factor receptor activity Biological Process: brain development; immune response; induction of apoptosis via death domain receptors; inflammatory response; negative regulation of apoptosis; positive regulation of JNK cascade; positive regulation of MAPKKK cascade; regulation of cell proliferation; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway Disease: Lymphoproliferative Syndrome 2
NCBI Summary:	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]
UniProt Code:	P26842
NCBI GenInfo Identifier:	269849546
NCBI Gene ID:	939
NCBI Accession:	P26842.2
UniProt Secondary Accession:	P26842,B2RDZ0,
UniProt Related Accession:	P26842
Molecular Weight:	29,137 Da
NCBI Full Name:	CD27 antigen
NCBI Synonym Full Names:	CD27 molecule
NCBI Official Symbol:	CD27
NCBI Official Synonym Symbols:	T14; S152; Tp55; TNFRSF7; S152. LPFS2
NCBI Protein Information:	CD27 antigen
UniProt Protein Name:	CD27 antigen
UniProt Synonym Protein Names:	CD27L receptor; T-cell activation antigen CD27; T14; Tumor necrosis factor receptor superfamily member 7; CD_antigen: CD27
Protein Family:	CD27 antigen
UniProt Gene Name:	CD27
UniProt Entry Name:	CD27_HUMAN