CD2 monoclonal antibody (AGIM0140)

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SKU:
AGIM0140
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
LT2
Conjugation:
Unconjugated
Applications:
FC
Frequently bought together:

Description

system_update_altDatasheet
Product Name:CD2 monoclonal antibody
Product Code:AGIM0140
Size:100 µg in 100 µL
Reactivity:Human
Clone:LT2
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgG2a
Host Species:Mouse
Storage:Store at 4°C. For long-term storage aliquot and store at -20°C. Avoidfreeze/thaw cycles.
Uniprot:P06729
Background:CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the twodimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. This material is offered for research only. Not for use in human. For in vitro use only. ImmunoTools will not be held responsible for patent infringement or other violations that may occur with the use of our products. .
UniProt Protein Function:CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: anchored to plasma membrane; cell surface; external side of plasma membrane; extracellular region; integral to plasma membrane; intercellular junction; internal side of plasma membrane; plasma membrane

Molecular Function:protein binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: apoptosis; cell surface receptor linked signal transduction; cell-cell adhesion; heterotypic cell-cell adhesion; leukocyte migration; lipid raft polarization; natural killer cell activation; positive regulation of myeloid dendritic cell activation; positive regulation of tumor necrosis factor production; regulation of T cell differentiation; T cell activation

NCBI Summary:CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]
UniProt Code:P06729
NCBI GenInfo Identifier:160370002
NCBI Gene ID:914
NCBI Accession:P06729.2
UniProt Secondary Accession:P06729,Q96TE5,
UniProt Related Accession:P06729
Molecular Weight:39,448 Da
NCBI Full Name:T-cell surface antigen CD2
NCBI Synonym Full Names:CD2 molecule
NCBI Official Symbol:CD2  
NCBI Official Synonym Symbols:T11; SRBC; LFA-2  
NCBI Protein Information:T-cell surface antigen CD2
UniProt Protein Name:T-cell surface antigen CD2
UniProt Synonym Protein Names:Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2
Protein Family:CD2
UniProt Gene Name:CD2  
UniProt Entry Name:CD2_HUMAN

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