CD1a monoclonal antibody (AGIM0019)
- SKU:
- AGIM0019
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- HI 149
- Conjugation:
- Unconjugated
- Applications:
- FC
Frequently bought together:
Description
system_update_altDatasheet
| Product Name: | CD1a monoclonal antibody |
| Product Code: | AGIM0019 |
| Size: | 100 µg in 100 µL |
| Reactivity: | Human |
| Clone: | HI 149 |
| Applications: | Flow Cytometry |
| Conjugate: | Unconjugated |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. |
| Uniprot: | P06126 |
| Background: | CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigenpresenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification. |
| UniProt Protein Function: | Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. |
| NCBI Summary: | This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Code: | P06126 |
| NCBI GenInfo Identifier: | 288558852 |
| NCBI Gene ID: | 909 |
| NCBI Accession: | P06126.4 |
| UniProt Related Accession: | P06126 |
| Molecular Weight: | |
| NCBI Full Name: | T-cell surface glycoprotein CD1a |
| NCBI Synonym Full Names: | CD1a molecule |
| NCBI Official Symbol: | CD1A |
| NCBI Official Synonym Symbols: | R4; T6; CD1; FCB6; HTA1 |
| NCBI Protein Information: | T-cell surface glycoprotein CD1a |
| UniProt Protein Name: | T-cell surface glycoprotein CD1a |
| UniProt Synonym Protein Names: | T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen; CD_antigen: CD1a |
| Protein Family: | CD109 antigen |
| UniProt Gene Name: | CD1A |
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