CD177 monoclonal antibody (FITC) (AGIM0094)

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SKU:
AGIM0094
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
MEM-166
Conjugation:
FITC
Applications:
FC
Frequently bought together:

Description

system_update_altDatasheet
Product Name:CD177 monoclonal antibody (FITC)
Product Code:AGIM0094
Size:500 µL
Reactivity:Human
Clone:MEM-166
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:Q8N6Q3
Background:CD177 (NB1/HNA-2a and PRV-1 form) is a GPI-anchored glycoprotein present mainly on neutrophils. Its plasma membrane expression is increased during pregnancy and and inflammation or after GCSF application. Ligand of CD177 has been identified as CD31 (PECAM-1). CD177 participates in neutrophil transmigration and seems to be also a pro-proliferative molecule. The antibodies against CD177 can be involved in neonatal alloimmune neutropenia (NAN).
UniProt Protein Function:CD177: Induced by CSF3 in resting granulocytes. Induced in patients with polycythemia vera (PV) and with essential thrombocythemia (ET). 3 isoforms of the human protein are produced by alternative splicing
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: plasma membrane

Biological Process: blood coagulation; leukocyte migration

NCBI Summary:This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]
UniProt Code:Q8N6Q3
NCBI GenInfo Identifier:91208246
NCBI Gene ID:57126
NCBI Accession:Q8N6Q3.2
UniProt Secondary Accession:Q8N6Q3,Q711Q2, Q8NCV9, Q96QH1, Q9HDA5,
UniProt Related Accession:Q8N6Q3
Molecular Weight:437
NCBI Full Name:CD177 antigen
NCBI Synonym Full Names:CD177 molecule
NCBI Official Symbol:CD177  
NCBI Official Synonym Symbols:NB1; PRV1; HNA2A; PRV-1; HNA-2a; NB1 GP  
NCBI Protein Information:CD177 antigen; NB1 glycoprotein; cell surface receptor; human neutrophil alloantigen 2a; polycythemia rubra vera protein 1
UniProt Protein Name:CD177 antigen
UniProt Synonym Protein Names:Human neutrophil alloantigen 2a; HNA-2a; NB1 glycoprotein; NB1 GP; Polycythemia rubra vera protein 1; PRV-1; CD_antigen: CD177
Protein Family:CD177 antigen
UniProt Gene Name:CD177  
UniProt Entry Name:CD177_HUMAN

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