CD14 monoclonal antibody (APC) (AGIM0462)

(No reviews yet) Write a Review
SKU:
AGIM0462
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
18D11
Conjugation:
APC
Applications:
FC
Frequently bought together:

Description

system_update_altDatasheet
Product Name:CD14 monoclonal antibody (APC)
Product Code:AGIM0462
Size:100 µL
Reactivity:Human
Clone:18D11
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Do not freeze. Avoid prolonged exposure to light.
Uniprot:P08571
Background:CD14 is a 55 kDa GPI-anchored glycoprotein, constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils, where serves as a multifunctional lipopolysaccharide receptor; it is also released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 is able to discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. CD14 affects allergic, inflammatory and infectious processes.
UniProt Protein Function:CD14: Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor

Cellular Component: anchored to external side of plasma membrane; extracellular space; cell surface; membrane; plasma membrane; lipopolysaccharide receptor complex; lipid raft; external side of plasma membrane

Molecular Function:lipopolysaccharide binding

Biological Process: response to bacterium; immune system process; response to molecule of bacterial origin; innate immune response; positive regulation of endocytosis; positive regulation of tumor necrosis factor production; inflammatory response; positive regulation of cytokine secretion

NCBI Summary:This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte/macrophage cells. This gene product acts as a co-receptor that binds several microbial and fungal molecules, including lipopolysaccharides (LPS). This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex. The product of this gene is found in two forms, either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor. [provided by RefSeq, Jul 2014]
UniProt Code:P08571
NCBI GenInfo Identifier:6753332
NCBI Gene ID:12475
NCBI Accession:NP_033971.1
UniProt Related Accession:P10810
Molecular Weight:
NCBI Full Name:monocyte differentiation antigen CD14
NCBI Synonym Full Names:CD14 antigen
NCBI Official Symbol:Cd14  
NCBI Protein Information:monocyte differentiation antigen CD14
UniProt Protein Name:Monocyte differentiation antigen CD14
UniProt Synonym Protein Names:Myeloid cell-specific leucine-rich glycoprotein; CD_antigen: CD14
Protein Family:Monocyte differentiation antigen
UniProt Gene Name:Cd14  
UniProt Entry Name:CD14_MOUSE

0 Reviews

View AllClose

Related Products