| UniProt Protein Function: | CBY1: Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Belongs to the chibby family.Protein type: Transcription regulationChromosomal Location of Human Ortholog: 22q12Cellular Component: cytosol; nucleoplasm; nucleus; trans-Golgi networkMolecular Function: beta-catenin binding; identical protein binding; protein bindingBiological Process: cardiac muscle cell differentiation; fat cell differentiation; negative regulation of transcription, DNA-dependent; negative regulation of Wnt receptor signaling pathway; protein localization |
| UniProt Protein Details: | |
| NCBI Summary: | Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y3M2 |
| NCBI GenInfo Identifier: | 20454882 |
| NCBI Gene ID: | 25776 |
| NCBI Accession: | Q9Y3M2.1 |
| UniProt Secondary Accession: | Q9Y3M2,Q66GT6, Q9UIK9, B2R4S2 |
| UniProt Related Accession: | Q9Y3M2 |
| Molecular Weight: | 14,470 Da |
| NCBI Full Name: | Protein chibby homolog 1 |
| NCBI Synonym Full Names: | chibby family member 1, beta catenin antagonist |
| NCBI Official Symbol: | CBY1 |
| NCBI Official Synonym Symbols: | CBY; arb1; PGEA1; C22orf2; PIGEA14; PIGEA-14; HS508I15A |
| NCBI Protein Information: | protein chibby homolog 1 |
| UniProt Protein Name: | Protein chibby homolog 1 |
| UniProt Synonym Protein Names: | ARPP-binding protein; Cytosolic leucine-rich protein; PIGEA-14; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1 |
| Protein Family: | Protein chibby |
| UniProt Gene Name: | CBY1 |
| UniProt Entry Name: | CBY1_HUMAN |
