CBX4 Antibody (PACO42895)
- SKU:
- PACO42895
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | CBX4 Antibody (PACO42895) |
Antibody SKU: | PACO42895 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human E3 SUMO-protein ligase CBX4 protein (401-560AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human breast cancer using PACO42895 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO42895 at dilution of 1:100. |
Background: | E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
Synonyms: | E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2), CBX4 |
UniProt Protein Function: | CBX4: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 6.3.2.-; SUMO ligase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: nucleoplasm; nucleus; PcG protein complex Molecular Function:enzyme binding; protein binding; SUMO binding; SUMO ligase activity; transcription corepressor activity Biological Process: negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein sumoylation |
UniProt Code: | O00257 |
NCBI GenInfo Identifier: | 254763424 |
NCBI Gene ID: | 8535 |
NCBI Accession: | O00257.3 |
UniProt Secondary Accession: | O00257,Q6TPI8, Q96C04, B1PJR7, |
UniProt Related Accession: | O00257 |
Molecular Weight: | 31,987 Da |
NCBI Full Name: | E3 SUMO-protein ligase CBX4 |
NCBI Synonym Full Names: | chromobox 4 |
NCBI Official Symbol: | CBX4 |
NCBI Official Synonym Symbols: | PC2; NBP16 |
NCBI Protein Information: | E3 SUMO-protein ligase CBX4 |
UniProt Protein Name: | E3 SUMO-protein ligase CBX4 |
UniProt Synonym Protein Names: | Chromobox protein homolog 4; Polycomb 2 homolog; Pc2; hPc2 |
Protein Family: | E3 SUMO-protein ligase |
UniProt Gene Name: | CBX4 |
UniProt Entry Name: | CBX4_HUMAN |