Canine IL2 Recombinant Protein (RPPB0490)
- SKU:
- RPPB0490
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Canine
- Target:
- IL2
- Synonyms:
- Interleukin-2
- IL-2
- T-cell growth factor
- TCGF
- Source:
- Escherichia Coli
- Uniprot:
- Q29416
Description
| Product Name: | Canine IL2 Recombinant Protein |
| Product Code: | RPPB0490 |
| Size: | 5µg |
| Species: | Canine |
| Target: | IL2 |
| Synonyms: | Interleukin-2, IL-2, T-cell growth factor, TCGF. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | IL2 Canine protein solution (0. 5mg/ml) contains Phosphate buffered saline (pH7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMAPITS SSTKETEQQM EQLLLDLQLL LNGVNNYENP QLSRMLTFKF YTPKKATEFT HLQCLAEELK NLEEVLGLPQ SKNVHLTDTK ELISNMNVTL LKLKGSETSY NCEYDDETAT ITEFLNKWIT FSQSIFSTLT |
| Biological Activity: | The ED50 measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells. is < 0.3 ng/ml. |
IL2 is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
IL2 Canine Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 160 amino acids (21-155 a.a) and having a molecular mass of 18.1 kDa.IL2 Canine is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. |
| UniProt Code: | Q29416 |
| NCBI GenInfo Identifier: | 3024011 |
| NCBI Gene ID: | 403989 |
| NCBI Accession: | Q29416.1 |
| UniProt Related Accession: | Q29416 |
| Molecular Weight: | |
| NCBI Full Name: | Interleukin-2 |
| NCBI Synonym Full Names: | interleukin 2 |
| NCBI Official Symbol: | IL2 |
| NCBI Protein Information: | interleukin-2 |
| UniProt Protein Name: | Interleukin-2 |
| UniProt Synonym Protein Names: | T-cell growth factor; TCGF |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL2 |
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