C1QB Antibody (PACO23420)
- SKU:
- PACO23420
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | C1QB Antibody (PACO23420) |
| Antibody SKU: | PACO23420 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:200, IF:1:100-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human C1QB. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from Jurkat cells, using C1QB antibody. |
 | Immunofluorescence analysis of A549 cells, using C1QB antibody. |
| Background: | C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca2+-dependent C1r2C1s2 proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. |
| Synonyms: | complement C1q subcomponent B; complement component 1; q subcomponent; B; |
| UniProt Protein Function: | C1QB: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QB are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p36.12 Cellular Component: collagen; complement component C1 complex; extracellular region Molecular Function:protein binding; protein homodimerization activity Biological Process: complement activation; complement activation, classical pathway; innate immune response; inner ear development Disease: C1q Deficiency |
| NCBI Summary: | This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02746 |
| NCBI GenInfo Identifier: | 298286922 |
| NCBI Gene ID: | 713 |
| NCBI Accession: | P02746.3 |
| UniProt Secondary Accession: | P02746,Q5T959, Q96H17, |
| UniProt Related Accession: | P02746 |
| Molecular Weight: | 26,722 Da |
| NCBI Full Name: | Complement C1q subcomponent subunit B |
| NCBI Synonym Full Names: | complement component 1, q subcomponent, B chain |
| NCBI Official Symbol: | C1QB |
| NCBI Protein Information: | complement C1q subcomponent subunit B |
| UniProt Protein Name: | Complement C1q subcomponent subunit B |
| Protein Family: | Complement C1q subcomponent |
| UniProt Gene Name: | C1QB |
| UniProt Entry Name: | C1QB_HUMAN |
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