Bet v 2.0101 Recombinant Protein (RPPB5275)

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SKU:
RPPB5275
Product type:
Recombinant Protein
Size:
100ug
Target:
Bet v 2.0101
Synonyms:
Profilin-1
Synonyms:
Allergen Bet v II
Synonyms:
Pollen allergen Bet v 2
Synonyms:
Bet v 2
Source:
Escherichia Coli
Uniprot:
P25816
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Description

Product Name:Bet v 2.0101 Recombinant Protein
Product Code:RPPB5275
Size:100µg
Target:Bet v 2.0101
Synonyms:Profilin-1, Allergen Bet v II, Pollen allergen Bet v 2, Bet v 2, BETVII, Bet v 2.0101.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:Bet v 2.0101 is supplied in 20mM HEPES buffer pH-7.9 and 6M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.

Profilin-1 (Bet v 2.0101) binds to actin and affects the structure of the cytoskeleton. At high concentrations, profiling-1 averts the polymerization of actin, whereas it augments it at low concentrations. By binding to PIP2, Profilin-1 inhibits the creation of IP3 and DG.

Recombinant Profilin-1 produced in E.coli is a non-glycosylated, polypeptide chain having a calculated molecular mass of 15,625 Dalton. Bet v 2.0101 is expressed with a 10xHis tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.MiscellaneousThe variability of the residues taking part of IgE-binding epitopes might be responsible of the difference in cross-reactivity among olive pollen cultivars, and between distantly related pollen species, leading to a variable range of allergy reactions among atopic patients.
UniProt Protein Details:
NCBI Summary:
UniProt Code:P25816
NCBI GenInfo Identifier:130975
NCBI Gene ID:
NCBI Accession:P25816.1
UniProt Secondary Accession:P25816
UniProt Related Accession:P25816
Molecular Weight:30.11 kDa
NCBI Full Name:Profilin-1
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:Profilin-1
UniProt Synonym Protein Names:Allergen Bet v II; Pollen allergen Bet v 2; Allergen: Bet v 2
Protein Family:
UniProt Gene Name:BETVII  
UniProt Entry Name:
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