ARFGAP1 Antibody (PACO04717)
- SKU:
- PACO04717
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | ARFGAP1 Antibody |
| Antibody SKU: | PACO04717 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat, Monkey |
| Immunogen: | synthesized peptide derived from the Internal region of human ARF GAP1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | ARFGAP1; ARF1GAP; ADP-ribosylation factor GTPase-activating protein 1; ARF GAP 1; ADP-ribosylation factor 1 GTPase-activating protein; ARF1 GAP; ARF1-directed GTPase-activating protein |
| UniProt Protein Function: | ARF GAP1: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; GAPs; GAPs, ARF Chromosomal Location of Human Ortholog: 20q13.33 Cellular Component: synapse; cytosol Molecular Function:protein binding; zinc ion binding; GTPase activator activity Biological Process: protein transport; unfolded protein response, activation of signaling protein activity; COPI coating of Golgi vesicle; cellular protein metabolic process; unfolded protein response; retrograde vesicle-mediated transport, Golgi to ER; positive regulation of GTPase activity |
| NCBI Summary: | The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q8N6T3 |
| NCBI GenInfo Identifier: | 27923731 |
| NCBI Gene ID: | 55738 |
| NCBI Accession: | Q8N6T3.2 |
| UniProt Secondary Accession: | Q8N6T3,Q6PK71, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0 B7Z3U0, B7Z8H8, B7ZBI3, E1P5I9, E7EV62, |
| UniProt Related Accession: | Q8N6T3 |
| Molecular Weight: | 406 |
| NCBI Full Name: | ADP-ribosylation factor GTPase-activating protein 1 |
| NCBI Synonym Full Names: | ADP-ribosylation factor GTPase activating protein 1 |
| NCBI Official Symbol: | ARFGAP1 |
| NCBI Official Synonym Symbols: | ARF1GAP; HRIHFB2281 |
| NCBI Protein Information: | ADP-ribosylation factor GTPase-activating protein 1; ARF1-directed GTPase-activating protein |
| UniProt Protein Name: | ADP-ribosylation factor GTPase-activating protein 1 |
| UniProt Synonym Protein Names: | ADP-ribosylation factor 1 GTPase-activating protein; ARF1 GAP; ARF1-directed GTPase-activating protein |
| Protein Family: | ADP-ribosylation factor GTPase-activating protein |
| UniProt Gene Name: | ARFGAP1 |
| UniProt Entry Name: | ARFG1_HUMAN |
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