APH1A Antibody (PACO07781)

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SKU:
PACO07781
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Application:
ELISA
Application:
WB
Antibody type:
Polyclonal
Conjugation:
Unconjugated
Frequently bought together:

Description

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Antibody Name:APH1A Antibody (PACO07781)
Antibody SKU:PACO07781
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human APH1A
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:anterior pharynx defective 1 homolog A (C. elegans);APH1A;6530402N02Rik;APH-1A;CGI-78 ;
UniProt Protein Function:APH1A: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the APH-1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Endoplasmic reticulum; Membrane protein, integral; Apoptosis; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p36.13-q31.3

Cellular Component: endoplasmic reticulum; Golgi apparatus; integral to plasma membrane; membrane; plasma membrane

Molecular Function:protein binding

Biological Process: amyloid precursor protein catabolic process; ephrin receptor signaling pathway; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; Notch receptor processing; Notch signaling pathway; positive regulation of apoptosis; positive regulation of catalytic activity; protein processing

NCBI Summary:This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]
UniProt Code:Q96BI3
NCBI GenInfo Identifier:37077707
NCBI Gene ID:51107
NCBI Accession:Q96BI3.1
UniProt Secondary Accession:Q96BI3,Q5TB22, Q5TB23, Q969R6, Q9BVG0, Q9Y386, B4DQK0
UniProt Related Accession:Q96BI3
Molecular Weight:20,977 Da
NCBI Full Name:Gamma-secretase subunit APH-1A
NCBI Synonym Full Names:aph-1 homolog A, gamma-secretase subunit
NCBI Official Symbol:APH1A  
NCBI Official Synonym Symbols:APH-1; APH-1A; CGI-78; 6530402N02Rik  
NCBI Protein Information:gamma-secretase subunit APH-1A
UniProt Protein Name:Gamma-secretase subunit APH-1A
UniProt Synonym Protein Names:Aph-1alpha; Presenilin-stabilization factor
Protein Family:Gamma-secretase
UniProt Gene Name:APH1A  
UniProt Entry Name:APH1A_HUMAN

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