Anti-ZSCAN4 Antibody (CAB12015)
- SKU:
- CAB12015
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-ZSCAN4 Antibody |
| Antibody SKU: | CAB12015 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human ZSCAN4 (NP_689890.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SH-SY5Y, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human ZSCAN4 (NP_689890.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MALD LRTI FQCE PSEN NLGS ENSA FQQS QGPA VQRE EGIS EFSR MVLN SFQD SNNS YARQ ELQR LYRI FHSW LQPE KHSK DEII SLLV LEQF MIGG HCND KASV KEKW KSSG KNLE RFIE DLTD DSIN PPAL VHVH MQGQ EALF SEDM PLRD VIVH LTKQ VNAQ TTRE ANMG TPSQ TSQD TSLE TGQG YEDE QDGW NSSS KTTR VNEN ITNQ GNQI VSLI IIQE ENGP RPEE GGVS SDNP YNSK RAEL VTAR SQEG SING ITFQ GVPM VMGA GCIS QPEQ SSPE SALT HQSN EGNS TCEV HQKG SHGV QK |
| Gene ID: | 201516 |
| Uniprot: | Q8NAM6 |
| Cellular Location: | Chromosome, Nucleus, telomere |
| Calculated MW: | 48kDa |
| Observed MW: | 49kDa |
| Synonyms: | ZSCAN4, ZNF494 |
| Background: |
| UniProt Protein Function: | ZSCAN4: Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; Transcription factor Chromosomal Location of Human Ortholog: 19q13.43 Cellular Component: nuclear chromosome, telomeric region Biological Process: negative regulation of mitotic recombination |
| NCBI Summary: | The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010] |
| UniProt Code: | Q8NAM6 |
| NCBI GenInfo Identifier: | 55976744 |
| NCBI Gene ID: | 201516 |
| NCBI Accession: | Q8NAM6.1 |
| UniProt Secondary Accession: | Q8NAM6,Q3MIQ2, |
| UniProt Related Accession: | Q8NAM6 |
| Molecular Weight: | 49kDa |
| NCBI Full Name: | Zinc finger and SCAN domain-containing protein 4 |
| NCBI Synonym Full Names: | zinc finger and SCAN domain containing 4 |
| NCBI Official Symbol: | ZSCAN4 |
| NCBI Official Synonym Symbols: | ZNF494 |
| NCBI Protein Information: | zinc finger and SCAN domain-containing protein 4 |
| UniProt Protein Name: | Zinc finger and SCAN domain-containing protein 4 |
| UniProt Synonym Protein Names: | Zinc finger protein 494 |
| Protein Family: | Zinc finger and SCAN domain-containing protein |
| UniProt Gene Name: | ZSCAN4 |
 | Western blot analysis of extracts of various cell lines, using ZSCAN4 antibody (CAB12015) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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