Anti-ZNF423 Antibody (CAB15795)
- SKU:
- CAB15795
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ZNF423 Antibody |
| Antibody SKU: | CAB15795 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-450 of human ZNF423 (NP_055884.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse eye, Rat eye |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 220-450 of human ZNF423 (NP_055884.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KPFK CTVC KRGF SSTS SLQS HMQA HKKN KEHL AKSE KEAK KDDF MCDY CEDT FSQT EELE KHVL TRHP QLSE KADL QCIH CPEV FVDE NTLL AHIH QAHA NQKH KCPM CPEQ FSSV EGVY CHLD SHRQ PDSS NHSV SPDP VLGS VASM SSAT PDSS ASVE RGST PDST LKPL RGQK KMRD DGQG WTKV VYSC PYCS KRDF NSLA VLEI HLKT IHAD KPQQ SHTC QICL DSM |
| Gene ID: | 23090 |
| Uniprot: | Q2M1K9 |
| Cellular Location: | Nucleus |
| Calculated MW: | 137kDa/144kDa |
| Observed MW: | 160kDa |
| Synonyms: | ZNF423, Ebfaz, JBTS19, NPHP14, OAZ, Roaz, ZFP423, Zfp104, hOAZ |
| Background: | The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ZNF423: Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. Defects in ZNF423 can be a cause of nephronophthisis-related ciliopathies (NPHP-RC), a group of recessive diseases that affect kidney, retina and brain. ZNF423 mutations have been found in patients with nephronophthisis, cerebellar vermis hypoplasia and situs inversus, and Joubert syndrome. Belongs to the krueppel C2H2-type zinc-finger protein family. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; DNA-binding Chromosomal Location of Human Ortholog: 16q12 Cellular Component: nucleus Molecular Function:protein binding Biological Process: negative regulation of transcription, DNA-dependent; Notch signaling pathway; positive regulation of BMP signaling pathway; positive regulation of transcription, DNA-dependent Disease: Nephronophthisis 14 |
| NCBI Summary: | The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2012] |
| UniProt Code: | Q2M1K9 |
| NCBI GenInfo Identifier: | 121941357 |
| NCBI Gene ID: | 23090 |
| NCBI Accession: | Q2M1K9.1 |
| UniProt Secondary Accession: | Q2M1K9,O94860, Q76N04, Q9NZ13, |
| UniProt Related Accession: | Q2M1K9 |
| Molecular Weight: | 137,950 Da |
| NCBI Full Name: | Zinc finger protein 423 |
| NCBI Synonym Full Names: | zinc finger protein 423 |
| NCBI Official Symbol: | ZNF423 |
| NCBI Official Synonym Symbols: | OAZ; Roaz; hOAZ; Ebfaz; JBTS19; NPHP14; ZFP423; Zfp104 |
| NCBI Protein Information: | zinc finger protein 423 |
| UniProt Protein Name: | Zinc finger protein 423 |
| UniProt Synonym Protein Names: | Olf1/EBF-associated zinc finger protein; hOAZ; Smad- and Olf-interacting zinc finger protein |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | ZNF423 |
| UniProt Entry Name: | ZN423_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ZNF423 antibody (CAB15795) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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