Anti-ZIP14 Antibody (CAB10413)
- SKU:
- CAB10413
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| Antibody Name: | Anti-ZIP14 Antibody |
| Antibody SKU: | CAB10413 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-340 of human ZIP14 (NP_001128626.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | LO2, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-340 of human ZIP14 (NP_001128626.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ILKI LLKQ KNEH HHGH SHYA SESL PSKK DQEE GVME KLQN GDLD HMIP QHCS SELD GKAP MVDE KVIV GSLS VQDL QASQ SACY WLKG VRYS DIGT LAWM I |
| Gene ID: | 23516 |
| Uniprot: | Q15043 |
| Cellular Location: | Cell membrane, Cell projection, Multi-pass membrane protein, lamellipodium |
| Calculated MW: | 52kDa/54kDa |
| Observed MW: | 50kDa |
| Synonyms: | SLC39A14, HMNDYT2, LZT-Hs4, NET34, ZIP14, cig19 |
| Background: |
| UniProt Protein Function: | SLC39A14: May mediate cellular uptake of nontransferrin-bound iron. Broad-scope metal ion transporter with a preference for zinc uptake. Belongs to the ZIP transporter (TC 2.A.5) family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 8p21.3 Cellular Component: cytoplasm; integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:zinc ion transmembrane transporter activity Biological Process: cellular zinc ion homeostasis Disease: Hypermanganesemia With Dystonia 2 |
| NCBI Summary: | Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q15043 |
| NCBI GenInfo Identifier: | 313104191 |
| NCBI Gene ID: | 23516 |
| NCBI Accession: | Q15043.3 |
| UniProt Secondary Accession: | Q15043,Q6ZME8, Q96BB3, A6NH98, B4DIW3, B6EU88, D3DSR4 |
| UniProt Related Accession: | Q15043 |
| Molecular Weight: | 54kDa |
| NCBI Full Name: | Zinc transporter ZIP14 |
| NCBI Synonym Full Names: | solute carrier family 39 member 14 |
| NCBI Official Symbol: | SLC39A14 |
| NCBI Official Synonym Symbols: | NET34; ZIP14; cig19; HMNDYT2; LZT-Hs4 |
| NCBI Protein Information: | zinc transporter ZIP14 |
| UniProt Protein Name: | Zinc transporter ZIP14 |
| UniProt Synonym Protein Names: | LIV-1 subfamily of ZIP zinc transporter 4; LZT-Hs4; Solute carrier family 39 member 14; Zrt- and Irt-like protein 14; ZIP-14 |
| Protein Family: | Zinc transporter |
| UniProt Gene Name: | SLC39A14 |
 | Western blot analysis of extracts of various cell lines, using ZIP14 antibody (CAB10413) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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