Anti-ZIC2 Antibody (CAB15736)
- SKU:
- CAB15736
- Product type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ZIC2 Antibody |
| Antibody SKU: | CAB15736 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ZIC2 (NP_009060.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse brain, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ZIC2 (NP_009060.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLLD AGPQ FPAI GVGS FARH HHHS AAAA AAAA AEMQ DREL SLAA AQNG FVDS AAAH MGAF KLNP GAHE LSPG QSSA FTSQ GPGA YPGS AAAA AAAA ALGP HAAH VGSY SGPP FNST RDFL FRSR GFGD SAPG GGQH GLFG PGAG GLHH AHSD AQGH LLFP GLPE QHGP HGSQ NVLN GQMR LGLP GEVF GRSE QYRQ VASP RTDP YSAA QLHN QYGP MNMN |
| Gene ID: | 7546 |
| Uniprot: | O95409 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 55kDa |
| Observed MW: | 50kDa |
| Synonyms: | ZIC2, HPE5 |
| Background: | This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Expansion of an alanine repeat in the C-terminus of the encoded protein and other mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. |
| NCBI Summary: | This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95409 |
| NCBI GenInfo Identifier: | 22547182 |
| NCBI Gene ID: | 7545 |
| NCBI Accession: | NP_003403.2 |
| UniProt Secondary Accession: | O95409,O95409, O60481, |
| UniProt Related Accession: | Q15915 |
| Molecular Weight: | |
| NCBI Full Name: | zinc finger protein ZIC 1 |
| NCBI Synonym Full Names: | Zic family member 1 |
| NCBI Official Symbol: | ZIC1 |
| NCBI Official Synonym Symbols: | ZIC; CRS6; ZNF201 |
| NCBI Protein Information: | zinc finger protein ZIC 1 |
| UniProt Protein Name: | Zinc finger protein ZIC 1 |
| UniProt Synonym Protein Names: | Zinc finger protein 201; Zinc finger protein of the cerebellum 1 |
| UniProt Gene Name: | ZIC1 |
| UniProt Entry Name: | ZIC1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ZIC2 antibody (CAB15736) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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