Anti-ZFX Antibody (CAB16444)
- SKU:
- CAB16444
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-ZFX Antibody |
| Antibody SKU: | CAB16444 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human ZFX (NP_003401.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | H460, HL-60, Mouse testis, Mouse lung, Mouse spleen, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human ZFX (NP_003401.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VLVA DCAS EAVI DANG IPVD QQDD DKGN CEDY LMIS LDDA GKIE HDGS SGMT MDTE SEID PCKV DGTC PEVI KVYI FKAD PGED DLGG TVDI VESE PEND HGVE LLDQ NSSI RVPR EKMV YMTV NDSQ PEDE DLNV AEIA DEVY MEVI VGEE DAAA AAAA AAVH EQQM DDNE IKTF MPIA WAAA YGNN SDGI ENRN GTAS A |
| Gene ID: | 7543 |
| Uniprot: | P17010 |
| Cellular Location: | Nucleus |
| Calculated MW: | 66kDa/90kDa/94kDa |
| Observed MW: | 110kDa |
| Synonyms: | ZFX, ZNF926 |
| Background: | This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. |
| UniProt Protein Function: | ZFX: Probable transcriptional activator. Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: Xp21.3 Molecular Function:DNA binding; transcription coactivator activity; transcription factor activity Biological Process: multicellular organismal development; regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010] |
| UniProt Code: | P17010 |
| NCBI GenInfo Identifier: | 68844748 |
| NCBI Gene ID: | 7543 |
| NCBI Accession: | P17010.2 |
| UniProt Secondary Accession: | P17010,O43668, Q8WYJ8, B9EG97, |
| UniProt Related Accession: | P17010 |
| Molecular Weight: | 94,386 Da |
| NCBI Full Name: | Zinc finger X-chromosomal protein |
| NCBI Synonym Full Names: | zinc finger protein, X-linked |
| NCBI Official Symbol: | ZFX |
| NCBI Official Synonym Symbols: | ZNF926 |
| NCBI Protein Information: | zinc finger X-chromosomal protein |
| UniProt Protein Name: | Zinc finger X-chromosomal protein |
| Protein Family: | Zinc-containing ferredoxin |
| UniProt Gene Name: | ZFX |
| UniProt Entry Name: | ZFX_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ZFX antibody (CAB16444) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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