Anti-ZFP36L1 Antibody (CAB8809)
- SKU:
- CAB8809
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-ZFP36L1 Antibody |
| Antibody SKU: | CAB8809 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-338 of human ZFP36L1 (NP_004917.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SKOV3, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-338 of human ZFP36L1 (NP_004917.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTTT LVSA TIFD LSEV LCKG NKML NYSA PSAG GCLL DRKA VGTP AGGG FPRR HSVT LPSS KFHQ NQLL SSLK GEPA PALS SRDS RFRD RSFS EGGE RLLP TQKQ PGGG QVNS SRYK TELC RPFE ENGA CKYG DKCQ FAHG IHEL RSLT RHPK YKTE LCRT FHTI GFCP YGPR CHFI HNAE ERRA LAGA RDLS ADRP RLQH SFSF AGFP SAAA TAAA TGLL DSPT SITP PPIL SADD LLGS PTLP DGTN NPFA FSSQ ELAS LFAP SMGL PGGG SPTT FLFR PMSE SPHM FDSP PSPQ DSLS DQEG YLSS SSSS HSGS DSPT LDNS RRLP IFSR LSIS DD |
| Gene ID: | 677 |
| Uniprot: | Q07352 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 36kDa |
| Observed MW: | 45-50kDa |
| Synonyms: | ZFP36L1, BRF1, Berg36, ERF-1, ERF1, RNF162B, TIS11B, cMG1 |
| Background: | This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail. Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation. May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation. Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA. Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development. Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation. |
| NCBI Summary: | This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q07352 |
| NCBI GenInfo Identifier: | 347659004 |
| NCBI Gene ID: | 677 |
| NCBI Accession: | NP_001231627.1 |
| UniProt Secondary Accession: | Q07352,Q13851, |
| UniProt Related Accession: | Q07352 |
| Molecular Weight: | 36 kDa |
| NCBI Full Name: | mRNA decay activator protein ZFP36L1 isoform 1 |
| NCBI Synonym Full Names: | ZFP36 ring finger protein like 1 |
| NCBI Official Symbol: | ZFP36L1 |
| NCBI Official Synonym Symbols: | BRF1; ERF1; cMG1; ERF-1; Berg36; TIS11B; RNF162B |
| NCBI Protein Information: | mRNA decay activator protein ZFP36L1 |
| UniProt Protein Name: | mRNA decay activator protein ZFP36L1 |
| UniProt Synonym Protein Names: | Butyrate response factor 1 |
| Protein Family: | Small toxic protein |
| UniProt Gene Name: | ZFP36L1 |
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