Anti-YY1 Antibody (CAB19569)
- SKU:
- CAB19569
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| Antibody Name: | Anti-YY1 Antibody |
| Antibody SKU: | CAB19569 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human YY1. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse kidney, Mouse spleen, Rat spleen, U-251MG, HeLa, Jurkat, Raji |
| Immunogen: | A synthesized peptide derived from human YY1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7528 |
| Uniprot: | P25490 |
| Cellular Location: | |
| Calculated MW: | 68kDa |
| Observed MW: | 68KDa |
 | Western blot - YY1 Rabbit mAb (CAB19569) |
| Synonyms: | DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, YY1 |
| Background: | YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). |
| NCBI Summary: | YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P25490 |
| NCBI GenInfo Identifier: | 3915889 |
| NCBI Gene ID: | 7528 |
| NCBI Accession: | P25490.2 |
| UniProt Secondary Accession: | P25490,Q14935, |
| UniProt Related Accession: | P25490 |
| Molecular Weight: | 44,713 Da |
| NCBI Full Name: | Transcriptional repressor protein YY1 |
| NCBI Synonym Full Names: | YY1 transcription factor |
| NCBI Official Symbol: | YY1 |
| NCBI Official Synonym Symbols: | DELTA; NF-E1; UCRBP; INO80S; YIN-YANG-1 |
| NCBI Protein Information: | transcriptional repressor protein YY1 |
| UniProt Protein Name: | Transcriptional repressor protein YY1 |
| UniProt Synonym Protein Names: | Delta transcription factor; INO80 complex subunit S; NF-E1; Yin and yang 1; YY-1 |
| Protein Family: | YY1-associated factor |
| UniProt Gene Name: | YY1 |
| UniProt Entry Name: | TYY1_HUMAN |
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