Anti-YES1 Antibody (CAB0628)
- SKU:
- CAB0628
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-YES1 Antibody |
| Antibody SKU: | CAB0628 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human YES1 (NP_005424.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 |
| Reactivity: | Human, Mouse |
| Positive Samples: | BT-474, HepG2, Mouse liver, Mouse kidney, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human YES1 (NP_005424.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGCI KSKE NKSP AIKY RPEN TPEP VSTS VSHY GAEP TTVS PCPS SSAK GTAV NFSS LSMT PFGG SSGV TPFG GASS SFSV VPSS YPAG LTGG VTIF VALY DYEA RTTE DLSF KKGE RFQI INNT EGDW WEAR SIAT GKNG YIPS NYVA PADS IQAE EWYF GKMG RKDA ERLL LNPG NQRG IFLV RESE TTKG AYSL SIRD WDEI RGDN VKHY KIRK LDNG GYYI TTRA QFDT LQKL VKHY TEHA DGLC HK |
| Gene ID: | 7525 |
| Uniprot: | P07947 |
| Cellular Location: | Cell membrane, Cytoplasm, centrosome, cytoskeleton, cytosol, microtubule organizing center |
| Calculated MW: | 60kDa |
| Observed MW: | 61kDa |
| Synonyms: | YES1, HsT441, P61-YES, Yes, c-yes |
| Background: | This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. |
| UniProt Protein Function: | Yes: a proto-oncogenic cytosolic tyrosine kinase of the Src family. Expressed at high levels in adult neurons, spermatozoa, platelets, and epithelial cells. |
| UniProt Protein Details: | Protein type:Protein kinase, TK; EC 2.7.10.2; Kinase, protein; Oncoprotein; Protein kinase, tyrosine (non-receptor); TK group; Src family Chromosomal Location of Human Ortholog: 18p11.31-p11.21 Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; Golgi apparatus; plasma membrane Molecular Function:enzyme binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding Biological Process: cell differentiation; ephrin receptor signaling pathway; innate immune response; leukocyte migration; protein modification process; regulation of cell proliferation; regulation of vascular permeability; T cell costimulation; transmembrane receptor protein tyrosine kinase signaling pathway |
| NCBI Summary: | This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P07947 |
| NCBI GenInfo Identifier: | 125870 |
| NCBI Gene ID: | 7525 |
| NCBI Accession: | P07947.3 |
| UniProt Secondary Accession: | P07947,A6NLB3, D3DUH1, |
| UniProt Related Accession: | P07947 |
| Molecular Weight: | 60,801 Da |
| NCBI Full Name: | Tyrosine-protein kinase Yes |
| NCBI Synonym Full Names: | YES proto-oncogene 1, Src family tyrosine kinase |
| NCBI Official Symbol: | YES1 |
| NCBI Official Synonym Symbols: | Yes; c-yes; HsT441; P61-YES |
| NCBI Protein Information: | tyrosine-protein kinase Yes |
| UniProt Protein Name: | Tyrosine-protein kinase Yes |
| UniProt Synonym Protein Names: | Proto-oncogene c-Yes; p61-Yes |
| Protein Family: | Tyrosine-protein kinase |
| UniProt Gene Name: | YES1 |
| UniProt Entry Name: | YES_HUMAN |
 | Western blot analysis of extracts of various cell lines, using YES1 antibody (CAB0628) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
 | Immunohistochemistry of paraffin-embedded mouse brain using YES1 antibody (CAB0628) at dilution of 1:100 (40x lens). |
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