Anti-XPNPEP2 Antibody (CAB10255)
- SKU:
- CAB10255
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-XPNPEP2 Antibody |
| Antibody SKU: | CAB10255 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-240 of human XPNPEP2 (NP_003390.4). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, A-549, HepG2, HT-29, SW480, Mouse kidney, Mouse heart, Mouse small intestine, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-240 of human XPNPEP2 (NP_003390.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HTKP VDLG GQDV RNCS TNPP YLPV TVVN TTMS LTAL RQQM QTQN LSAY IIPG TDAH MNEY IGQH DERR AWIT GFTG SAGT AVVT MKKA AVWT DSRY WTQA ERQM DCNW ELHK EVGT TPIV TWLL TEIP AGGR VGFD PFLL SIDT WESY DLAL QGSN RQLV SITT NLVD LVWG SERP PVPN QPIY ALQE AFTG STWQ EKVS GVRS QMQK HQKV PTAV LLS |
| Gene ID: | 7512 |
| Uniprot: | O43895 |
| Cellular Location: | Cell membrane, GPI-anchor, Lipid-anchor |
| Calculated MW: | 75kDa |
| Observed MW: | 76kDa |
| Synonyms: | XPNPEP2, AEACEI, APP2 |
| Background: | Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. |
| UniProt Protein Function: | XPNPEP2: A metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin. Belongs to the peptidase M24B family. |
| UniProt Protein Details: | Protein type:EC 3.4.11.9; Membrane protein, GPI anchor; Protease Chromosomal Location of Human Ortholog: Xq26.1 Cellular Component: extracellular region; membrane; plasma membrane Molecular Function:aminopeptidase activity Biological Process: C-terminal protein lipidation Disease: Angioedema Induced By Ace Inhibitors, Susceptibility To |
| NCBI Summary: | Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43895 |
| NCBI GenInfo Identifier: | 25091514 |
| NCBI Gene ID: | 7512 |
| NCBI Accession: | O43895.3 |
| UniProt Secondary Accession: | O43895,O75994, A0AV16, |
| UniProt Related Accession: | O43895 |
| Molecular Weight: | 76kDa |
| NCBI Full Name: | Xaa-Pro aminopeptidase 2 |
| NCBI Synonym Full Names: | X-prolyl aminopeptidase 2 |
| NCBI Official Symbol: | XPNPEP2 |
| NCBI Official Synonym Symbols: | APP2; AEACEI |
| NCBI Protein Information: | xaa-Pro aminopeptidase 2 |
| UniProt Protein Name: | Xaa-Pro aminopeptidase 2 |
| UniProt Synonym Protein Names: | Aminoacylproline aminopeptidase; Membrane-bound aminopeptidase P; Membrane-bound APP; Membrane-bound AmP; mAmP; X-Pro aminopeptidase 2 |
| UniProt Gene Name: | XPNPEP2 |
 | Western blot analysis of extracts of various cell lines, using XPNPEP2 antibody (CAB10255) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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