Anti-WNT2 Antibody (CAB5864)

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SKU:
CAB5864
Product type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Frequently bought together:

Description

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Antibody Name:Anti-WNT2 Antibody
Antibody SKU:CAB5864
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-360 of human WNT2 (NP_003382.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:SKOV3
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-360 of human WNT2 (NP_003382.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SWWY MRAT GGSS RVMC DNVP GLVS SQRQ LCHR HPDV MRAI SQGV AEWT AECQ HQFR QHRW NCNT LDRD HSLF GRVL LRSS RESA FVYA ISSA GVVF AITR ACSQ GEVK SCSC DPKK MGSA KDSK GIFD WGGC SDNI DYGI KFAR AFVD AKER KGKD ARAL MNLH NNRA GRKA VKRF LKQE CKCH GVSG SCTL RTCW LAMA DFRK TGDY LWRK YNGA IQVV MNQD GTGF TVAN ERFK KPTK NDLV YFEN SPDY CIRD REAG SLGT AGRV CNLT SRGM DSCE VMCC GRGY DTSH VTRM TKCG CKFH WCCA VRCQ DCLE ALDV HTCK APKN ADWT TAT
Gene ID:7472
Uniprot:P09544
Cellular Location:Secreted, extracellular matrix, extracellular space
Calculated MW:40kDa
Observed MW:56kDa
Synonyms:WNT2, INT1L1, IRP
Background:This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene.
UniProt Protein Function:WNT2: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Belongs to the Wnt family.
UniProt Protein Details:

Protein type:Cell development/differentiation; Extracellular matrix; Secreted, signal peptide; Cell adhesion; Secreted

Chromosomal Location of Human Ortholog: 7q31.2

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; cytoplasm; plasma membrane; extracellular region

Molecular Function:protein binding; frizzled binding; cytokine activity; receptor agonist activity

Biological Process: lens development in camera-type eye; cell fate commitment; Wnt receptor signaling pathway; atrial cardiac muscle morphogenesis; Wnt receptor signaling pathway through beta-catenin; neuron differentiation; positive regulation of fibroblast proliferation; cell-cell signaling; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; positive regulation of transcription factor activity; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cardiac muscle cell proliferation; lung development

NCBI Summary:This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P09544
NCBI GenInfo Identifier:139750
NCBI Gene ID:7472
NCBI Accession:P09544.1
UniProt Secondary Accession:P09544,Q75N05, Q9UDP9, A4D0V1,
UniProt Related Accession:P09544
Molecular Weight:360
NCBI Full Name:Protein Wnt-2
NCBI Synonym Full Names:wingless-type MMTV integration site family member 2
NCBI Official Symbol:WNT2  
NCBI Official Synonym Symbols:IRP; INT1L1  
NCBI Protein Information:protein Wnt-2; int-1-like protein 1; Int-1-related protein; secreted growth factor
UniProt Protein Name:Protein Wnt-2
UniProt Synonym Protein Names:Int-1-like protein 1; Int-1-related protein; IRP
UniProt Gene Name:WNT2  
UniProt Entry Name:WNT2_HUMAN
Anti-WNT2 Antibody (CAB5864)Western blot analysis of extracts of SKOV3 cells, using WNT2 Antibody (CAB5864) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s.
Anti-WNT2 Antibody (CAB5864)Immunohistochemistry of paraffin-embedded rat brain using WNT2 antibody (CAB5864) at dilution of 1:200 (40x lens).
Anti-WNT2 Antibody (CAB5864)Immunohistochemistry of paraffin-embedded human liver damage using WNT2 antibody (CAB5864) at dilution of 1:200 (40x lens).

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