Anti-WNT2 Antibody (CAB13562)
- SKU:
- CAB13562
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-WNT2 Antibody |
| Antibody SKU: | CAB13562 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human WNT2 (NP_003382.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Rat liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human WNT2 (NP_003382.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNAP LGGI WLWL PLLL TWLT PEVN SSWW YMRA TGGS SRVM CDNV PGLV SSQR QLCH RHPD VMRA ISQG VAEW TAEC QHQF RQHR WNCN TLDR DHSL FGRV |
| Gene ID: | 7472 |
| Uniprot: | P09544 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 40kDa |
| Observed MW: | 50kDa |
| Synonyms: | WNT2, INT1L1, IRP |
| Background: | This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. |
| UniProt Protein Function: | WNT2: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Belongs to the Wnt family. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Extracellular matrix; Secreted, signal peptide; Cell adhesion; Secreted Chromosomal Location of Human Ortholog: 7q31.2 Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; cytoplasm; plasma membrane; extracellular region Molecular Function:protein binding; frizzled binding; cytokine activity; receptor agonist activity Biological Process: lens development in camera-type eye; cell fate commitment; Wnt receptor signaling pathway; atrial cardiac muscle morphogenesis; Wnt receptor signaling pathway through beta-catenin; neuron differentiation; positive regulation of fibroblast proliferation; cell-cell signaling; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; positive regulation of transcription factor activity; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cardiac muscle cell proliferation; lung development |
| NCBI Summary: | This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09544 |
| NCBI GenInfo Identifier: | 139750 |
| NCBI Gene ID: | 7472 |
| NCBI Accession: | P09544.1 |
| UniProt Secondary Accession: | P09544,Q75N05, Q9UDP9, A4D0V1, |
| UniProt Related Accession: | P09544 |
| Molecular Weight: | 360 |
| NCBI Full Name: | Protein Wnt-2 |
| NCBI Synonym Full Names: | wingless-type MMTV integration site family member 2 |
| NCBI Official Symbol: | WNT2 |
| NCBI Official Synonym Symbols: | IRP; INT1L1 |
| NCBI Protein Information: | protein Wnt-2; int-1-like protein 1; Int-1-related protein; secreted growth factor |
| UniProt Protein Name: | Protein Wnt-2 |
| UniProt Synonym Protein Names: | Int-1-like protein 1; Int-1-related protein; IRP |
| UniProt Gene Name: | WNT2 |
| UniProt Entry Name: | WNT2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using WNT2 Antibody (CAB13562) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of human placenta using WNT2 Rabbit pAb (CAB13562) at dilution of 1:250 (40x lens). Blue: DAPI for nuclear staining. |
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