| UniProt Protein Function: | WDR61: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of MLL1; it promotes leukemogenesis though association with MLL-rearranged oncoproteins, such as MLL-MLLT3/AF9 and MLL-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1C. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 15q25.1 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:protein binding Biological Process: negative regulation of myeloid cell differentiation; positive regulation of histone H3-K4 methylation; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9GZS3 |
| NCBI GenInfo Identifier: | 74761365 |
| NCBI Gene ID: | 80349 |
| NCBI Accession: | Q9GZS3.1 |
| UniProt Secondary Accession: | Q9GZS3,Q6IA22, Q7Z4X4, D3DW84, |
| UniProt Related Accession: | Q9GZS3 |
| Molecular Weight: | 33,581 Da |
| NCBI Full Name: | WD repeat-containing protein 61 |
| NCBI Synonym Full Names: | WD repeat domain 61 |
| NCBI Official Symbol: | WDR61 |
| NCBI Official Synonym Symbols: | SKI8; REC14 |
| NCBI Protein Information: | WD repeat-containing protein 61 |
| UniProt Protein Name: | WD repeat-containing protein 61 |
| UniProt Synonym Protein Names: | Meiotic recombination REC14 protein homolog; SKI8 homolog; Ski8 |
| Protein Family: | WD repeat-containing protein |
| UniProt Gene Name: | WDR61 |
| UniProt Entry Name: | WDR61_HUMAN |
