| UniProt Protein Function: | WAVE2: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1. Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. Belongs to the SCAR/WAVE family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Actin-bindingChromosomal Location of Human Ortholog: 1p36.11Cellular Component: actin cytoskeleton; cytosol; intracellular; lamellipodiumMolecular Function: protein binding; protein complex bindingBiological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of stress fiber formation; vascular endothelial growth factor receptor signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] |
| UniProt Code: | Q9Y6W5 |
| NCBI GenInfo Identifier: | 59800456 |
| NCBI Gene ID: | 10163 |
| NCBI Accession: | Q9Y6W5.3 |
| UniProt Secondary Accession: | Q9Y6W5,O60794, Q9UDY7, B4DZN0 |
| UniProt Related Accession: | Q9Y6W5 |
| Molecular Weight: | 31,979 Da |
| NCBI Full Name: | Wiskott-Aldrich syndrome protein family member 2 |
| NCBI Synonym Full Names: | WAS protein family member 2 |
| NCBI Official Symbol: | WASF2 |
| NCBI Official Synonym Symbols: | IMD2; SCAR2; WASF4; WAVE2; dJ393P12.2 |
| NCBI Protein Information: | wiskott-Aldrich syndrome protein family member 2 |
| UniProt Protein Name: | Wiskott-Aldrich syndrome protein family member 2 |
| UniProt Synonym Protein Names: | Protein WAVE-2; Verprolin homology domain-containing protein 2 |
| Protein Family: | Wiskott-Aldrich syndrome protein family |
| UniProt Gene Name: | WASF2 |
| UniProt Entry Name: | WASF2_HUMAN |
