Anti-VLDLR Antibody (CAB7345)
- SKU:
- CAB7345
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-VLDLR Antibody |
| Antibody SKU: | CAB7345 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-210 of human VLDLR (NP_001018066.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | THP-1, Mouse lung, Mouse ovary |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-210 of human VLDLR (NP_001018066.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RESG ATGT GRKA KCEP SQFQ CTNG RCIT LLWK CDGD EDCV DGSD EKNC VKKT CAES DFVC NNGQ CVPS RWKC DGDP DCED GSDE SPEQ CHMR TCRI HEIS CGAH STQC IPVS WRCD GEND CDSG EDEE NCGN ITCS PDEF TCSS GRCI SRNF VCNG QDDC SDGS DELD CAPP TCGA HEFQ CSTS SCIP ISW |
| Gene ID: | 7436 |
| Uniprot: | P98155 |
| Cellular Location: | Membrane, Single-pass type I membrane protein, clathrin-coated pit |
| Calculated MW: | 93kDa/96kDa |
| Observed MW: | 110kDa |
| Synonyms: | VLDLR, CAMRQ1, CARMQ1, CHRMQ1, VLDL-R, VLDLRCH |
| Background: | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. |
| UniProt Protein Function: | VLDLR: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1); also known as dysequilibrium syndrome (DES) or non- progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 9p24 Cellular Component: membrane; plasma membrane; integral to membrane; coated pit; receptor complex Molecular Function:very-low-density lipoprotein receptor activity; low-density lipoprotein receptor activity; very-low-density lipoprotein binding; protein binding; apolipoprotein binding; calcium ion binding; glycoprotein binding; calcium-dependent protein binding Biological Process: nervous system development; receptor-mediated endocytosis; cholesterol metabolic process; positive regulation of protein kinase activity; ventral spinal cord development; negative regulation of transcription from RNA polymerase II promoter; signal transduction; lipid transport; memory Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1 |
| NCBI Summary: | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009] |
| UniProt Code: | P98155 |
| NCBI GenInfo Identifier: | 65301167 |
| NCBI Gene ID: | 7436 |
| NCBI Accession: | NP_003374.3 |
| UniProt Secondary Accession: | P98155,Q5VVF6, B2RMZ7, D3DRH6, |
| UniProt Related Accession: | P98155 |
| Molecular Weight: | 96,098 Da |
| NCBI Full Name: | very low-density lipoprotein receptor isoform a |
| NCBI Synonym Full Names: | very low density lipoprotein receptor |
| NCBI Official Symbol: | VLDLR |
| NCBI Official Synonym Symbols: | CARMQ1; CHRMQ1; VLDLRCH |
| NCBI Protein Information: | very low-density lipoprotein receptor; VLDL-R; VLDL receptor |
| UniProt Protein Name: | Very low-density lipoprotein receptor |
| Protein Family: | Very low-density lipoprotein receptor |
| UniProt Gene Name: | VLDLR |
| UniProt Entry Name: | VLDLR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using VLDLR antibody (CAB7345) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
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