Anti-VEGFC Antibody (CAB2556)

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SKU:
CAB2556
Product type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cardiovascular
Frequently bought together:

Description

Anti-VEGFC Antibody

VEGFC protein is encoded by the VEGFC gene and plays an important role in cancer progression. VEGFC has been shown to be overexpressed in several cancer types, including breast, pancreatic, lung and colon cancers. It can also be found over expressed in cardiovascular disease and diabetic complications as well. The Anti-VEGFC antibody from Assay Genie can be used in Western Blot and Immunohistochemistry applications.

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Antibody Name:Anti-VEGFC Antibody
Antibody SKU:CAB2556
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human VEGFC
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:BT-474, MCF7, Mouse spleen, Rat liver, Mouse heart, Mouse brain
Immunogen:A synthetic peptide of human VEGFC
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7424
Uniprot:P49767
Cellular Location:Secreted
Calculated MW:46kDa
Observed MW:47kDa
Synonyms:VEGFC, Flt4-L, LMPH1D, VRP
Background:The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors.
UniProt Protein Function:VEGFC: Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Homodimer; non-covalent and antiparallel. Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. Belongs to the PDGF/VEGF growth factor family.
UniProt Protein Details:

Protein type:Cell cycle regulation; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 4q34.3

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function:protein binding; growth factor activity; vascular endothelial growth factor receptor 3 binding; chemoattractant activity

Biological Process: signal transduction; induction of positive chemotaxis; negative regulation of cell proliferation; morphogenesis of embryonic epithelium; platelet degranulation; positive chemotaxis; regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of cell proliferation; negative regulation of blood pressure; angiogenesis; positive regulation of cell-matrix adhesion; response to drug; substrate-bound cell migration; positive regulation of neuroblast proliferation; platelet activation; positive regulation of blood vessel endothelial cell migration; positive regulation of protein amino acid autophosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; organ morphogenesis; positive regulation of angiogenesis; positive regulation of protein secretion; positive regulation of cell division; blood coagulation; vascular endothelial growth factor receptor signaling pathway; positive regulation of epithelial cell proliferation

Disease: Lymphedema, Hereditary, Id

NCBI Summary:The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]
UniProt Code:P49767
NCBI GenInfo Identifier:1718154
NCBI Gene ID:7424
NCBI Accession:P49767.1
UniProt Secondary Accession:P49767,B2R9Q8,
UniProt Related Accession:P49767
Molecular Weight:46,883 Da
NCBI Full Name:Vascular endothelial growth factor C
NCBI Synonym Full Names:vascular endothelial growth factor C
NCBI Official Symbol:VEGFC
NCBI Official Synonym Symbols:VRP; Flt4-L; LMPH1D
NCBI Protein Information:vascular endothelial growth factor C; FLT4 ligand DHM; vascular endothelial growth factor-related protein
UniProt Protein Name:Vascular endothelial growth factor C
UniProt Synonym Protein Names:Flt4 ligand; Flt4-L; Vascular endothelial growth factor-related protein; VRP
Protein Family:Vascular endothelial growth factor
UniProt Gene Name:VEGFC
UniProt Entry Name:VEGFC_HUMAN
Anti-VEGFC Antibody (CAB2556)Western blot analysis of extracts of various cell lines, using VEGFC antibody (CAB2556) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-VEGFC Antibody (CAB2556)Western blot analysis of extracts of various cell lines, using VEGFC antibody (CAB2556) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-VEGFC Antibody (CAB2556)Immunohistochemistry of paraffin-embedded mouse brain using VEGFC antibody (CAB2556) (40x lens).
Anti-VEGFC Antibody (CAB2556)Immunohistochemistry of paraffin-embedded rat brain using VEGFC antibody (CAB2556) (40x lens).

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