Anti-VDAC1 / Porin Antibody (CAB0810)
- SKU:
- CAB0810
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-VDAC1 / Porin Antibody |
| Antibody SKU: | CAB0810 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human VDAC1 / Porin (NP_003365.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, A-431, Mouse brain, Mouse kidney, Rat brain, Rat kidney, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human VDAC1 / Porin (NP_003365.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAVP PTYA DLGK SARD VFTK GYGF GLIK LDLK TKSE NGLE FTSS GSAN TETT KVTG SLET KYRW TEYG LTFT EKWN TDNT LGTE ITVE DQLA RGLK LTFD SSFS PNTG KKNA KIKT GYKR EHIN LGCD MDFD IAGP SIRG ALVL GYEG WLAG YQMN FETA KSRV TQSN FAVG YKTD EFQL HTNV NDGT EFGG SIYQ KVNK KLET AVNL AWTA GNSN TRFG IAAK YQID PDAC FSAK VNNS SLIG LGYT QTLK PGIK LTLS ALLD GKNV NAGG HKLG LGLE FQA |
| Gene ID: | 7416 |
| Uniprot: | P21796 |
| Cellular Location: | Cell membrane, Membrane raft, Mitochondrion outer membrane, Multi-pass membrane protein |
| Calculated MW: | 30kDa |
| Observed MW: | 31KDa |
| Synonyms: | PORIN, VDAC-1, VDAC1, VDAC1 / Porin |
| Background: | This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y. |
| UniProt Protein Function: | VDAC1: a protein of the eukaryotic mitochondrial porin family. Forms a voltage-dependent anion channel through the mitochondrial outer membrane and also the plasma membrane. The channel allows diffusion of small hydrophilic molecules; it adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, misc.; Mitochondrial Chromosomal Location of Human Ortholog: 5q31 Cellular Component: lipid raft; membrane; mitochondrial outer membrane; mitochondrion; myelin sheath; nucleus; plasma membrane; pore complex; synaptic vesicle Molecular Function:porin activity; protein binding; protein complex binding; protein kinase binding; voltage-gated anion channel activity Biological Process: anion transport; apoptosis; behavioral fear response; epithelial cell differentiation; learning; macroautophagy; macromitophagy; mitochondrial calcium ion transport; nerve-nerve synaptic transmission; viral reproduction |
| NCBI Summary: | This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010] |
| UniProt Code: | P21796 |
| NCBI GenInfo Identifier: | 130683 |
| NCBI Gene ID: | 7416 |
| NCBI Accession: | P21796.2 |
| UniProt Secondary Accession: | P21796,Q5FVE7, Q9UIQ5, Q9UPL0, B3KVK4, D3DQ93, |
| UniProt Related Accession: | P21796 |
| Molecular Weight: | 30,773 Da |
| NCBI Full Name: | Voltage-dependent anion-selective channel protein 1 |
| NCBI Synonym Full Names: | voltage dependent anion channel 1 |
| NCBI Official Symbol: | VDAC1 |
| NCBI Official Synonym Symbols: | PORIN; VDAC-1 |
| NCBI Protein Information: | voltage-dependent anion-selective channel protein 1 |
| UniProt Protein Name: | Voltage-dependent anion-selective channel protein 1 |
| UniProt Synonym Protein Names: | Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM |
| Protein Family: | Porin |
| UniProt Gene Name: | VDAC1 |
| UniProt Entry Name: | VDAC1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using VDAC1 / Porin Rabbit pAb (CAB0810) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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