Anti-VCP Antibody (CAB1402)
- SKU:
- CAB1402
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Autophagy
Description
| Antibody Name: | Anti-VCP Antibody |
| Antibody SKU: | CAB1402 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human VCP |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, K-562, SH-SY5Y, Mouse brain, Mouse spleen, Mouse kidney, Rat liver, Rat brain |
| Immunogen: | A synthesized peptide derived from human VCP |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7415 |
| Uniprot: | P55072 |
| Cellular Location: | |
| Calculated MW: | 89kDa |
| Observed MW: | 97KDa |
 | Western blot - VCP Rabbit mAb (CAB1402) |
| Synonyms: | ALS14, CDC48, CMT2Y, HEL-220, HEL-S-70, IBMPFD, IBMPFD1, TERA, p97 |
| Background: | The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | VCP: valosin-containing protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope and of the transitional endoplasmic reticulum (tER). Regulates NFKappaB pathway, which is important for metastasis of osteosarcoma. Tyrosine phosphorylation regulates its cell cycle-dependent nuclear localization. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; EC 3.6.4.6; DNA repair, damage; Chaperone; Hydrolase Chromosomal Location of Human Ortholog: 9p13.3 Cellular Component: nucleoplasm; proteasome complex; endoplasmic reticulum membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; lipid particle; cytosol; nucleus Molecular Function:protein domain specific binding; identical protein binding; protein binding; ATPase activity; protein complex binding; ADP binding; polyubiquitin binding; protein phosphatase binding; lipid binding; ATP binding; receptor binding Biological Process: caspase activation; proteasomal ubiquitin-dependent protein catabolic process; ER to Golgi vesicle-mediated transport; ER-associated protein catabolic process; unfolded protein response; protein ubiquitination; DNA repair; regulation of apoptosis; retrograde protein transport, ER to cytosol; bypass DNA synthesis; establishment of protein localization; positive regulation of protein complex assembly; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; double-strand break repair; positive regulation of protein catabolic process; protein amino acid N-linked glycosylation via asparagine; response to DNA damage stimulus; protein homooligomerization Disease: Amyotrophic Lateral Sclerosis 14, With Or Without Frontotemporal Dementia; Inclusion Body Myopathy With Early-onset Paget Disease With Or Without Frontotemporal Dementia 1 |
| NCBI Summary: | The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P55072 |
| NCBI GenInfo Identifier: | 6094447 |
| NCBI Gene ID: | 7415 |
| NCBI Accession: | P55072.4 |
| UniProt Secondary Accession: | P55072,Q0V924, Q2TAI5, Q969G7, Q9UCD5, B2R5T8, |
| UniProt Related Accession: | P55072 |
| Molecular Weight: | 89,322 Da |
| NCBI Full Name: | Transitional endoplasmic reticulum ATPase |
| NCBI Synonym Full Names: | valosin containing protein |
| NCBI Official Symbol: | VCP |
| NCBI Official Synonym Symbols: | p97; TERA; ALS14; IBMPFD |
| NCBI Protein Information: | transitional endoplasmic reticulum ATPase; TER ATPase; yeast Cdc48p homolog; valosin-containing protein; 15S Mg(2+)-ATPase p97 subunit |
| UniProt Protein Name: | Transitional endoplasmic reticulum ATPase |
| UniProt Synonym Protein Names: | 15S Mg(2+)-ATPase p97 subunit; Valosin-containing protein |
| Protein Family: | Transitional endoplasmic reticulum ATPase |
| UniProt Gene Name: | VCP |
| UniProt Entry Name: | TERA_HUMAN |
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