Anti-VARS2 Antibody (CAB15484)
- SKU:
- CAB15484
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-VARS2 Antibody |
| Antibody SKU: | CAB15484 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 864-1063 of human VARS2 (NP_065175.4). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-251MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 864-1063 of human VARS2 (NP_065175.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LWQR LPPR PGCP PAPS ISVA PYPS ACSL EHWR QPEL ERRF SRVQ EVVQ VLRA LRAT YQLT KARP RVLL QSSE PGDQ GLFE AFLE PLGT LGYC GAVG LLPP GAAA PSGW AQAP LSDT AQVY MELQ GLVD PQIQ LPLL AARR YKLQ KQLD SLTA RTPS EGEA GTQR QQKL SSLQ LELS KLDK AASH LRQL MDEP PAPG SPEL |
| Gene ID: | 57176 |
| Uniprot: | Q5ST30 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 55kDa/102kDa/118kDa/121kDa |
| Observed MW: | 120kDa |
| Synonyms: | VARS2, COXPD20, VALRS, VARS2L, VARSL |
| Background: | This gene encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial encephalopathies. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | VARS2: Belongs to the class-I aminoacyl-tRNA synthetase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Translation; EC 6.1.1.9; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Ligase Chromosomal Location of Human Ortholog: 6p21.33 Cellular Component: cytosol Molecular Function:valine-tRNA ligase activity Biological Process: valyl-tRNA aminoacylation Disease: Combined Oxidative Phosphorylation Deficiency 20 |
| NCBI Summary: | This gene encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial encephalopathies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2014] |
| UniProt Code: | Q5ST30 |
| NCBI GenInfo Identifier: | 109731090 |
| NCBI Gene ID: | 57176 |
| NCBI Accession: | BC113605 |
| UniProt Secondary Accession: | Q5ST30,Q2M2A0, Q59FI1, Q5SQ96, Q5SS98, Q6DKJ5, Q6ZV24 A2ABL7, B4DET4, B4E3P5, F5GXJ0, F5H323, |
| UniProt Related Accession: | Q5ST30 |
| Molecular Weight: | 121,543 Da |
| NCBI Full Name: | Homo sapiens valyl-tRNA synthetase 2, mitochondrial (putative), mRNA |
| NCBI Synonym Full Names: | valyl-tRNA synthetase 2, mitochondrial |
| NCBI Official Symbol: | VARS2 |
| NCBI Official Synonym Symbols: | VALRS; VARSL; VARS2L; COXPD20 |
| NCBI Protein Information: | valine--tRNA ligase, mitochondrial |
| UniProt Protein Name: | Valine--tRNA ligase, mitochondrial |
| UniProt Synonym Protein Names: | Valyl-tRNA synthetase; ValRS; Valyl-tRNA synthetase-like |
| UniProt Gene Name: | VARS2 |
| UniProt Entry Name: | SYVM_HUMAN |
 | Western blot analysis of extracts of U-251MG cells, using VARS2 antibody (CAB15484) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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