Anti-VAMP8 Antibody (CAB13915)
- SKU:
- CAB13915
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Autophagy
Frequently bought together:
Description
| Antibody Name: | Anti-VAMP8 Antibody |
| Antibody SKU: | CAB13915 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-75 of human VAMP8 (NP_003752.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, NIH/3T3, PC-12, Mouse kidney, Mouse liver, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-75 of human VAMP8 (NP_003752.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEEA SEGG GNDR VRNL QSEV EGVK NIMT QNVE RILA RGEN LEHL RNKT EDLE ATSE HFKT TSQK VARK FWWK NVK |
| Gene ID: | 8673 |
| Uniprot: | Q9BV40 |
| Cellular Location: | Cell membrane, Early endosome membrane, Late endosome membrane, Lysosome membrane, Single-pass type IV membrane protein |
| Calculated MW: | 11kDa |
| Observed MW: | 11kDa |
| Synonyms: | VAMP8, EDB, VAMP-8 |
| Background: | This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane. |
| UniProt Protein Function: | VAMP8: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Belongs to the synaptobrevin family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Vesicle Chromosomal Location of Human Ortholog: 2p12-p11.2 Cellular Component: cytoplasm; cytosol; early endosome; late endosome membrane; lysosomal membrane; membrane; perinuclear region of cytoplasm; plasma membrane; recycling endosome; secretory granule membrane; SNARE complex; vesicle Molecular Function:chloride channel inhibitor activity; protein binding; SNAP receptor activity; SNARE binding Biological Process: entry of virus into host cell; eosinophil degranulation; neutrophil degranulation; post-Golgi vesicle-mediated transport; vesicle fusion |
| NCBI Summary: | This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010] |
| UniProt Code: | Q9BV40 |
| NCBI GenInfo Identifier: | 55976764 |
| NCBI Gene ID: | 8673 |
| NCBI Accession: | Q9BV40.1 |
| UniProt Secondary Accession: | Q9BV40,O60625, Q53SP9, Q6IB09, |
| UniProt Related Accession: | Q9BV40 |
| Molecular Weight: | 11,438 Da |
| NCBI Full Name: | Vesicle-associated membrane protein 8 |
| NCBI Synonym Full Names: | vesicle associated membrane protein 8 |
| NCBI Official Symbol: | VAMP8 |
| NCBI Official Synonym Symbols: | EDB; VAMP-8 |
| NCBI Protein Information: | vesicle-associated membrane protein 8 |
| UniProt Protein Name: | Vesicle-associated membrane protein 8 |
| UniProt Synonym Protein Names: | Endobrevin |
| Protein Family: | Vesicle-associated membrane protein |
| UniProt Gene Name: | VAMP8 |
| UniProt Entry Name: | VAMP8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using VAMP8 antibody (CAB13915) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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