Anti-UTS2 Antibody (CAB5334)
- SKU:
- CAB5334
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-UTS2 Antibody |
| Antibody SKU: | CAB5334 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-124 of human UTS2 (NP_006777.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse skeletal muscle, Mouse testis, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 35-124 of human UTS2 (NP_006777.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | APHE DARL TPEE LERA SLLQ ILPE MLGA ERGD ILRK ADSS TNIF NPRG NLRK FQDF SGQD PNIL LSHL LARI WKPY KKRE TPDC FWKY CV |
| Gene ID: | 10911 |
| Uniprot: | O95399 |
| Cellular Location: | Secreted |
| Calculated MW: | 14kDa/16kDa |
| Observed MW: | 17kDa |
| Synonyms: | UTS2, PRO1068, U-II, UCN2, UII |
| Background: | This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. |
| UniProt Protein Function: | UTS2: Highly potent vasoconstrictor. Belongs to the urotensin-2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p36 Cellular Component: extracellular region Molecular Function:receptor binding Biological Process: muscle contraction; regulation of blood pressure; synaptic transmission |
| NCBI Summary: | This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95399 |
| NCBI GenInfo Identifier: | 9087195 |
| NCBI Gene ID: | 10911 |
| NCBI Accession: | O95399.1 |
| UniProt Secondary Accession: | O95399,Q5H8X7, Q6UXF6, Q9UKP7, |
| UniProt Related Accession: | O95399 |
| Molecular Weight: | 16,029 Da |
| NCBI Full Name: | Urotensin-2 |
| NCBI Synonym Full Names: | urotensin 2 |
| NCBI Official Symbol: | UTS2 |
| NCBI Official Synonym Symbols: | UII; U-II; UCN2; PRO1068 |
| NCBI Protein Information: | urotensin-2 |
| UniProt Protein Name: | Urotensin-2 |
| UniProt Synonym Protein Names: | Urotensin II; U-II; UII |
| UniProt Gene Name: | UTS2 |
| UniProt Entry Name: | UTS2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UTS2 antibody (CAB5334) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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