Anti-USP47 Antibody (CAB15461)
- SKU:
- CAB15461
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| Antibody Name: | Anti-USP47 Antibody |
| Antibody SKU: | CAB15461 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1128-1287 of human USP47 (NP_060414.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Jurkat, HeLa, SGC-7901, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1128-1287 of human USP47 (NP_060414.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VEKM KSMS QLAV LSRR WKPS EMKL DPFQ EVVL ESSS VDEL REKL SEIS GIPL DDIE FAKG RGTF PCDI SVLD IHQD LDWN PKVS TLNV WPLY ICDD GAVI FYRD KTEE LMEL TDEQ RNEL MKKE SSRL QKTG HRVT YSPR KEKA LKIY LDGA PNKD LTQD |
| Gene ID: | 55031 |
| Uniprot: | Q96K76 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 18kDa/147kDa/154kDa/157kDa |
| Observed MW: | 180kDa |
| Synonyms: | USP47, TRFP |
| Background: |
| UniProt Protein Function: | USP47: Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.19.12; Ubiquitin-specific protease; Motility/polarity/chemotaxis; Actin-binding; Protease; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 11p15.3 Cellular Component: cytoplasm; nucleus; SCF ubiquitin ligase complex Molecular Function:protein binding; ubiquitin-specific protease activity Biological Process: base-excision repair; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of transcription, DNA-dependent; positive regulation of cell growth; response to DNA damage stimulus; response to drug |
| UniProt Code: | Q96K76 |
| NCBI GenInfo Identifier: | 313104266 |
| NCBI Gene ID: | 55031 |
| NCBI Accession: | Q96K76.3 |
| UniProt Secondary Accession: | Q96K76,Q658U0, Q86Y73, Q8TEP6, Q9BWI0, Q9NWN1, B3KXF5 E9PM46, |
| UniProt Related Accession: | Q96K76 |
| Molecular Weight: | 154,697 Da |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 47 |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 47 |
| NCBI Official Symbol: | USP47 |
| NCBI Official Synonym Symbols: | TRFP |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 47 |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 47 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme 47; Ubiquitin thioesterase 47; Ubiquitin-specific-processing protease 47 |
| Protein Family: | Ubiquitin carboxyl-terminal hydrolase |
| UniProt Gene Name: | USP47 |
| UniProt Entry Name: | UBP47_HUMAN |
 | Western blot analysis of extracts of various cell lines, using USP47 Rabbit pAb (CAB15461) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded Human colon carcinoma using USP47 Rabbit pAb (CAB15461) at dilution of 1:100 (40x lens). |
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