| UniProt Protein Function: | USP46: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. Belongs to the peptidase C19 family. USP12/USP46 subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; EC 3.4.19.12; Ubiquitin-specific protease Chromosomal Location of Human Ortholog: 4q12 Molecular Function:protein binding; ubiquitin-specific protease activity Biological Process: ubiquitin-dependent protein catabolic process; protein deubiquitination; behavioral fear response; righting reflex; adult feeding behavior; behavioral response to ethanol; regulation of synaptic transmission, GABAergic |
| NCBI Summary: | Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009] |
| UniProt Code: | P62068 |
| NCBI GenInfo Identifier: | 49065850 |
| NCBI Gene ID: | 64854 |
| NCBI Accession: | P62068.1 |
| UniProt Secondary Accession: | P62068,Q80V95, Q9H7U4, Q9H9T8, B7Z3Y7, B7Z675, B7Z7S3 G8ACC7, |
| UniProt Related Accession: | P62068 |
| Molecular Weight: | 366 |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 46 |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 46 |
| NCBI Official Symbol: | USP46 |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 46; ubiquitin thioesterase 46; deubiquitinating enzyme 46; ubiquitin thiolesterase 46; ubiquitin-specific-processing protease 46 |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 46 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46 |
| Protein Family: | Ubiquitin carboxyl-terminal hydrolase |
| UniProt Gene Name: | USP46 |
| UniProt Entry Name: | UBP46_HUMAN |
