Anti-UNC5C Antibody (CAB14809)
- SKU:
- CAB14809
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-UNC5C Antibody |
| Antibody SKU: | CAB14809 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-360 of human UNC5C (NP_003719.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, 293T, Mouse brain, Mouse lung, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-360 of human UNC5C (NP_003719.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EGQS VQKI ACTT LCPV DGRW TPWS KWST CGTE CTHW RRRE CTAP APKN GGKD CDGL VLQS K |
| Gene ID: | 8633 |
| Uniprot: | O95185 |
| Cellular Location: | Cell junction, Cell membrane, Single-pass type I membrane protein, synapse, synaptosome |
| Calculated MW: | 66kDa/103kDa |
| Observed MW: | 103kDa |
| Synonyms: | UNC5C, UNC5H3 |
| Background: | This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. |
| UniProt Protein Function: | UNC5C: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Belongs to the unc-5 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 4q21-q23 Cellular Component: integral to membrane; plasma membrane Molecular Function:netrin receptor activity Biological Process: axon guidance; apoptosis; positive regulation of apoptosis; brain development; regulation of cell migration; anterior/posterior axon guidance |
| NCBI Summary: | This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95185 |
| NCBI GenInfo Identifier: | 229462767 |
| NCBI Gene ID: | 8633 |
| NCBI Accession: | O95185.2 |
| UniProt Related Accession: | O95185 |
| Molecular Weight: | |
| NCBI Full Name: | Netrin receptor UNC5C |
| NCBI Synonym Full Names: | unc-5 netrin receptor C |
| NCBI Official Symbol: | UNC5C |
| NCBI Official Synonym Symbols: | UNC5H3 |
| NCBI Protein Information: | netrin receptor UNC5C |
| UniProt Protein Name: | Netrin receptor UNC5C |
| UniProt Synonym Protein Names: | Protein unc-5 homolog 3; Protein unc-5 homolog C |
| Protein Family: | UNC5C-like protein |
| UniProt Gene Name: | UNC5C |
| UniProt Entry Name: | UNC5C_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UNC5C antibody (CAB14809) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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