Anti-ULBP1 Antibody (CAB10483)
- SKU:
- CAB10483
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| Antibody Name: | Anti-ULBP1 Antibody |
| Antibody SKU: | CAB10483 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-216 of human ULBP1 (NP_079494.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Raji |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-216 of human ULBP1 (NP_079494.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GWVD THCL CYDF IITP KSRP EPQW CEVQ GLVD ERPF LHYD CVNH KAKA FASL GKKV NVTK TWEE QTET LRDV VDFL KGQL LDIQ VENL IPIE PLTL QARM SCEH EAHG HGRG SWQF LFNG QKFL LFDS NNRK WTAL HPGA KKMT EKWE KNRD VTMF FQKI SLGD CKMW LEEF LMYW EQML DPTK PPSL APG |
| Gene ID: | 80329 |
| Uniprot: | Q9BZM6 |
| Cellular Location: | Cell membrane, Endoplasmic reticulum, GPI-anchor, Lipid-anchor |
| Calculated MW: | 27kDa |
| Observed MW: | 28kDa |
| Synonyms: | ULBP1, N2DL-1, NKG2DL1, RAET1I |
| Background: | The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ULBP1: Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis- Golgi apparatus so that it does not reach the cell surface. Belongs to the MHC class I family. |
| UniProt Protein Details: | Protein type:Apoptosis; Cell surface; Membrane protein, GPI anchor Chromosomal Location of Human Ortholog: 6q25.1 Cellular Component: actin cytoskeleton; anchored to plasma membrane; cytosol; plasma membrane Molecular Function:antigen binding; natural killer cell lectin-like receptor binding Biological Process: antigen processing and presentation; natural killer cell activation; natural killer cell mediated cytotoxicity; regulation of immune response |
| NCBI Summary: | The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] |
| UniProt Code: | Q9BZM6 |
| NCBI GenInfo Identifier: | 47605924 |
| NCBI Gene ID: | 80329 |
| NCBI Accession: | Q9BZM6.1 |
| UniProt Secondary Accession: | Q9BZM6,Q5VY81, Q8IZW3, Q8IZX6, |
| UniProt Related Accession: | Q9BZM6 |
| Molecular Weight: | 28kDa |
| NCBI Full Name: | NKG2D ligand 1 |
| NCBI Synonym Full Names: | UL16 binding protein 1 |
| NCBI Official Symbol: | ULBP1 |
| NCBI Official Synonym Symbols: | N2DL-1; RAET1I; NKG2DL1 |
| NCBI Protein Information: | NKG2D ligand 1 |
| UniProt Protein Name: | NKG2D ligand 1 |
| UniProt Synonym Protein Names: | ALCAN-beta; Retinoic acid early transcript 1I; UL16-binding protein 1 |
| Protein Family: | NKG2D ligand |
| UniProt Gene Name: | ULBP1 |
 | Western blot analysis of extracts of Raji cells, using ULBP1 antibody (CAB10483) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded human tonsil using ULBP1 Rabbit pAb (CAB10483) at dilution of 1:500 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using ULBP1 Rabbit pAb (CAB10483) at dilution of 1:500 (40x lens). |
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