Anti-UHRF2 Antibody (CAB13602)
- SKU:
- CAB13602
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| Antibody Name: | Anti-UHRF2 Antibody |
| Antibody SKU: | CAB13602 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 441-622 of human UHRF2 (NP_690856.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 441-622 of human UHRF2 (NP_690856.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IVPS NHYG PIPG IPVG STWR FRVQ VSEA GVHR PHVG GIHG RSND GAYS LVLA GGFA DEVD RGDE FTYT GSGG KNLA GNKR IGAP SADQ TLTN MNRA LALN CDAP LDDK IGAE SRNW RAGK PVRV IRSF KGRK ISKY APEE GNRY DGIY KVVK YWPE ISSS HGFL VWRY LLRR DDVE PAPW TS |
| Gene ID: | 115426 |
| Uniprot: | Q96PU4 |
| Cellular Location: | Nucleus |
| Calculated MW: | 56kDa/89kDa |
| Observed MW: | Refer to figures |
| Synonyms: | UHRF2, NIRF, RNF107, TDRD23, URF2 |
| Background: | This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. |
| UniProt Protein Function: | UHRF2: E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Appears to contribute to tumorigenesis. Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 6.3.2.-; Ubiquitin conjugating system; EC 6.3.2.19; Ubiquitin ligase; Cell cycle regulation; Ligase Chromosomal Location of Human Ortholog: 9p24.1 Cellular Component: nucleoplasm; nuclear heterochromatin; nucleus Molecular Function:protein binding; DNA binding; zinc ion binding; histone binding; ubiquitin-protein ligase activity; ligase activity Biological Process: ubiquitin-dependent protein catabolic process; cell proliferation; protein autoubiquitination; regulation of cell cycle; protein ubiquitination; cell differentiation; cell cycle |
| UniProt Code: | Q96PU4 |
| NCBI GenInfo Identifier: | 67462076 |
| NCBI Gene ID: | |
| NCBI Accession: | Q96PU4.1 |
| Molecular Weight: | 56kDa; 89kDa |
| NCBI Full Name: | E3 ubiquitin-protein ligase UHRF2 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase UHRF2 |
| UniProt Synonym Protein Names: | Np95/ICBP90-like RING finger protein; Np95-like RING finger protein; Nuclear protein 97; Nuclear zinc finger protein Np97; RING finger protein 107; Ubiquitin-like PHD and RING finger domain-containing protein 2; Ubiquitin-like-containing PHD and RING finger domains protein 2 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | UHRF2 |
| UniProt Entry Name: | UHRF2_HUMAN |
 | Immunohistochemistry of paraffin-embedded rat Intestine using UHRF2 antibody (CAB13602) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human kidney cancer using UHRF2 antibody (CAB13602) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse liver using UHRF2 antibody (CAB13602) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of U-2 OS cells using UHRF2 antibody (CAB13602) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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