Anti-UGT1A10 Antibody (CAB16537)
- SKU:
- CAB16537
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-UGT1A10 Antibody |
| Antibody SKU: | CAB16537 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human UGT1A10 (NP_061948.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | LO2, 293T, A375 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human UGT1A10 (NP_061948.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LRGH EVVV VMPE VSWQ LERS LNCT VKTY STSY TLED QNRE FMVF AHAQ WKAQ AQSI FSLL MSSS SGFL DLFF SHCR SLFN DRKL VEYL KESS FDAV FLDP F |
| Gene ID: | 54575 |
| Uniprot: | Q9HAW8 |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome, Single-pass membrane protein |
| Calculated MW: | 49kDa/59kDa |
| Observed MW: | 60kDa |
| Synonyms: | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J |
| Background: | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. |
| UniProt Protein Function: | Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. |
| UniProt Protein Details: | Catalytic activity: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. Subcellular location: Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential. Tissue specificity: Liver and colon. Ref.1 Sequence similarities: Belongs to the UDP-glycosyltransferase family. |
| NCBI Summary: | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9HAW8 |
| NCBI GenInfo Identifier: | 29789078 |
| NCBI Gene ID: | 54575 |
| NCBI Accession: | NP_061948 |
| UniProt Related Accession: | Q9HAW8 |
| Molecular Weight: | |
| NCBI Full Name: | UDP-glucuronosyltransferase 1-10 |
| NCBI Synonym Full Names: | UDP glucuronosyltransferase family 1 member A10 |
| NCBI Official Symbol: | UGT1A10 |
| NCBI Official Synonym Symbols: | GNT1; UGT1; UDPGT; UGT1A; UGT1J; UGT-1A; UGT-1J; UGT1.1; UGT1A1; UGT1-01; UGT1-10; UGT1.10; hUG-BR1 |
| NCBI Protein Information: | UDP-glucuronosyltransferase 1-10 |
| UniProt Protein Name: | UDP-glucuronosyltransferase 1-10 |
| UniProt Synonym Protein Names: | UDP-glucuronosyltransferase 1-J; UGT-1J; UGT1J; UDP-glucuronosyltransferase 1A10 |
| Protein Family: | UDP-glucuronosyltransferase |
| UniProt Gene Name: | UGT1A10 |
| UniProt Entry Name: | UD110_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UGT1A10 antibody (CAB16537) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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