Anti-Ubiquityl-Histone H2A-K119 Antibody (CAB17952)

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SKU:
CAB17952
Product type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-Ubiquityl-Histone H2A-K119 Antibody
Antibody SKU:CAB17952
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human HIST1H2AB.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:NIH/3T3, C6
Immunogen:A synthetic peptide of human HIST1H2AB.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3012/8335
Uniprot:P04908
Cellular Location:
Calculated MW:
Observed MW:17KDa
Anti-Ubiquityl-Histone H2A-K119 Antibody (CAB17952)Western blot - Ubiquityl-Histone H2A-K119 Rabbit pAb (CAB17952)
Synonyms:HIST1H2AB
Background:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.H2A clustered histone (H2AC) consists of several H2A family members, which function as replication-dependent histone proteins.
UniProt Protein Function:HIST1H2AE: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 6p22.2

Cellular Component: nuclear chromatin; nucleus

Molecular Function:DNA binding

Biological Process: chromatin silencing; negative regulation of cell proliferation

NCBI Summary:Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
UniProt Code:P04908
NCBI GenInfo Identifier:124028530
NCBI Gene ID:3012
NCBI Accession:P04908.2
UniProt Secondary Accession:P04908,P28001, Q76P63,
UniProt Related Accession:P04908
Molecular Weight:14kDa
NCBI Full Name:Histone H2A type 1-B/E
NCBI Synonym Full Names:histone cluster 1 H2A family member e
NCBI Official Symbol:HIST1H2AE  
NCBI Official Synonym Symbols:H2A.1; H2A.2; H2A/a; H2AFA  
NCBI Protein Information:histone H2A type 1-B/E
UniProt Protein Name:Histone H2A type 1-B/E
UniProt Synonym Protein Names:Histone H2A.2; Histone H2A/a; Histone H2A/m
UniProt Gene Name:HIST1H2AB  

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