Anti-UBIAD1 Antibody (CAB7640)
- SKU:
- CAB7640
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-UBIAD1 Antibody |
| Antibody SKU: | CAB7640 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UBIAD1 (NP_037451.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse heart, Rat heart |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UBIAD1 (NP_037451.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAS QVLG EKIN ILSG ETVK AGDR DPLG NDCP EQDR LPQR SWRQ KCAS YVLA LRPW SFSA SLTP VALG SALA YRSH GVLD PRLL VGCA VAVL AVHG AGNL |
| Gene ID: | 29914 |
| Uniprot: | Q9Y5Z9 |
| Cellular Location: | Cytoplasm, Endoplasmic reticulum membrane, Golgi apparatus membrane, Mitochondrion membrane, Multi-pass membrane protein, Nucleus |
| Calculated MW: | 19kDa/36kDa |
| Observed MW: | 41kDa |
| Synonyms: | UBIAD1, SCCD, TERE1 |
| Background: | This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy. |
| UniProt Protein Function: | UBIAD1: Prenyltransferase that mediates the formation of menaquinone-4 (MK-4), a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas. Mediates the conversion of phylloquinone (PK) into menaquinone-4 (MK-4), probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Defects in UBIAD1 are the cause of crystalline corneal dystrophy of Schnyder (SCCD). SCCD is a rare autosomal dominant disease characterized by progressive corneal opacification resulting from abnormal deposition of cholesterol and phospholipids. Belongs to the UbiA prenyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.5.1.-; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; integral to Golgi membrane; membrane; nucleus Molecular Function:antioxidant activity; prenyltransferase activity; protein binding Biological Process: menaquinone biosynthetic process; ubiquinone biosynthetic process; ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate; vitamin K biosynthetic process; vitamin K metabolic process Disease: Schnyder Corneal Dystrophy |
| NCBI Summary: | This gene encodes a protein thought to be involved in cholesterol and phospholipid metabolism. Mutations in this gene are associated with Schnyder crystalline corneal dystrophy. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q9Y5Z9 |
| NCBI GenInfo Identifier: | 1057866085 |
| NCBI Gene ID: | 29914 |
| NCBI Accession: | |
| UniProt Secondary Accession: | Q9Y5Z9,Q53GX3, Q5THD4, B3KQG3, |
| UniProt Related Accession: | Q9Y5Z9 |
| Molecular Weight: | Calculated MW 19kDa/36kDaObserved MW 37kDa |
| NCBI Full Name: | ubiA prenyltransferase domain-containing protein 1 isoform 2 |
| NCBI Synonym Full Names: | UbiA prenyltransferase domain containing 1 |
| NCBI Official Symbol: | UBIAD1 |
| NCBI Official Synonym Symbols: | SCCD; TERE1 |
| NCBI Protein Information: | ubiA prenyltransferase domain-containing protein 1 |
| UniProt Protein Name: | UbiA prenyltransferase domain-containing protein 1 |
| UniProt Synonym Protein Names: | Transitional epithelial response protein 1 |
| Protein Family: | UbiA prenyltransferase domain-containing protein |
| UniProt Gene Name: | UBIAD1 |
| UniProt Entry Name: | UBIA1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using UBIAD1 antibody (CAB7640) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using UBIAD1 antibody (CAB7640) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human prostate using UBIAD1 antibody (CAB7640) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using UBIAD1 antibody (CAB7640) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using UBIAD1 antibody (CAB7640) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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