Anti-TXNRD2 Antibody (CAB8884)
- SKU:
- CAB8884
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-TXNRD2 Antibody |
| Antibody SKU: | CAB8884 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human TXNRD2 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, Mouse liver, Mouse spleen, Mouse kidney |
| Immunogen: | A synthesized peptide derived from human TXNRD2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 10587 |
| Uniprot: | Q9NNW7 |
| Cellular Location: | |
| Calculated MW: | 57kDa |
| Observed MW: | 56KDa |
| Synonyms: | SELZ, TR, TR-BETA, TR3, TRXR2 |
| Background: | This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013] |
| UniProt Protein Function: | TXNRD2: Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine; EC 1.8.1.9; Oxidoreductase Chromosomal Location of Human Ortholog: 22q11.21 Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:FAD binding; protein binding; thioredoxin-disulfide reductase activity Biological Process: cell redox homeostasis; response to oxygen radical; response to reactive oxygen species |
| NCBI Summary: | This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q9NNW7 |
| NCBI GenInfo Identifier: | 182705230 |
| NCBI Gene ID: | 10587 |
| NCBI Accession: | Q9NNW7.3 |
| UniProt Secondary Accession: | Q9NNW7,O95840, Q96IJ2, Q9H2Z5, Q9NZV3, Q9NZV4, Q9P2Y0 Q9P2Y1, Q9UQU8, |
| UniProt Related Accession: | Q9NNW7 |
| Molecular Weight: | 30,291 Da |
| NCBI Full Name: | Thioredoxin reductase 2, mitochondrial |
| NCBI Synonym Full Names: | thioredoxin reductase 2 |
| NCBI Official Symbol: | TXNRD2 |
| NCBI Official Synonym Symbols: | TR; TR3; SELZ; TRXR2; TR-BETA |
| NCBI Protein Information: | thioredoxin reductase 2, mitochondrial |
| UniProt Protein Name: | Thioredoxin reductase 2, mitochondrial |
| UniProt Synonym Protein Names: | Selenoprotein Z; SelZ; TR-beta; Thioredoxin reductase TR3 |
| Protein Family: | Thioredoxin reductase |
| UniProt Gene Name: | TXNRD2 |
| UniProt Entry Name: | TRXR2_HUMAN |
 | Western blot - TXNRD2 Rabbit mAb (CAB8884) |
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