Anti-TXNDC5 Antibody (CAB7315)

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SKU:
CAB7315
Product type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
Frequently bought together:

Description

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Antibody Name:Anti-TXNDC5 Antibody
Antibody SKU:CAB7315
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-324 of human TXNDC5 (NP_001139021.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:HepG2, HeLa, NCI-H460, SKOV3, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-324 of human TXNDC5 (NP_001139021.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MEDA KVYV AKVD CTAH SDVC SAQG VRGY PTLK LFKP GQEA VKYQ GPRD FQTL ENWM LQTL NEEP VTPE PEVE PPSA PELK QGLY ELSA SNFE LHVA QGDH FIKF FAPW CGHC KALA PTWE QLAL GLEH SETV KIGK VDCT QHYE LCSG NQVR GYPT LLWF RDGK KVDQ YKGK RDLE SLRE YVES QLQR TETG ATET VTPS EAPV LAAE PEAD KGTV LALT ENNF DDTI AEGI TFIK FYAP WCGH CKTL APTW EELS KKEF PGLA GVKI AEVD CTAE RNIC SKYS VRGY PTLL LFRG GKKV SEHS GGRD LDSL HRFV LSQA KDEL
Gene ID:81567
Uniprot:Q8NBS9
Cellular Location:Endoplasmic reticulum lumen
Calculated MW:36kDa/47kDa
Observed MW:48kDa
Synonyms:TXNDC5, ENDOPDI, ERP46, HCC-2, HCC2, PDIA15, STRF8, UNQ364
Background:This gene encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream MUTED (muted homolog) gene.
UniProt Protein Function:TXNDC5: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast. Belongs to the protein disulfide isomerase family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p24.3

Cellular Component: lysosomal lumen; endoplasmic reticulum; endoplasmic reticulum lumen

Molecular Function:protein binding; protein disulfide isomerase activity

Biological Process: protein folding; cell redox homeostasis; post-Golgi vesicle-mediated transport; apoptotic cell clearance; negative regulation of apoptosis

NCBI Summary:This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016]
UniProt Code:Q8NBS9
NCBI GenInfo Identifier:29839560
NCBI Gene ID:81567
NCBI Accession:Q8NBS9.2
UniProt Related Accession:Q8NBS9
Molecular Weight:
NCBI Full Name:Thioredoxin domain-containing protein 5
NCBI Synonym Full Names:thioredoxin domain containing 5
NCBI Official Symbol:TXNDC5  
NCBI Official Synonym Symbols:HCC2; ERP46; HCC-2; STRF8; PDIA15; UNQ364; ENDOPDI  
NCBI Protein Information:thioredoxin domain-containing protein 5
UniProt Protein Name:Thioredoxin domain-containing protein 5
UniProt Synonym Protein Names:Endoplasmic reticulum resident protein 46; ER protein 46; ERp46; Thioredoxin-like protein p46
UniProt Gene Name:TXNDC5  
UniProt Entry Name:TXND5_HUMAN
Anti-TXNDC5 Antibody (CAB7315)Western blot analysis of extracts of various cell lines, using TXNDC5 antibody (CAB7315) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-TXNDC5 Antibody (CAB7315)Immunofluorescence analysis of A-549 cells using TXNDC5 antibody (CAB7315). Blue: DAPI for nuclear staining.

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